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SARS-CoV-2 antibody kinetics in blood donors with a previously positive SARS-CoV-2 antibody test within a seroprevalence survey.
Levring, Mette B; Holm, Dorte K; Nilsson, Anna C; Bauer, Joschka M; Jensen, Iben S; Davidsen, Jesper R; Rasmussen, Line D; Sprogøe, Ulrik; Lillevang, Søren T.
  • Levring MB; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
  • Holm DK; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
  • Nilsson AC; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
  • Bauer JM; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
  • Jensen IS; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
  • Davidsen JR; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • Rasmussen LD; Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.
  • Sprogøe U; Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.
  • Lillevang ST; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
J Med Virol ; 94(4): 1711-1716, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1718398
ABSTRACT
The persistence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is a matter of importance regarding the coronavirus disease 19 (COVID-19) pandemic. To observe antibody dynamics, 105 blood donors, positive for SARS-CoV-2 antibodies by a lateral flow test within a seroprevalence study, were included in this study. Thirty-nine (37%) of 105 the donors were confirmed positive by a total Ig Wantai enzyme-linked immunosorbent assay (ELISA). Three (8%) in this group of 39 reported severe and 26/39 (67%) mild to moderate COVID-19 symptoms. By further ELISA-testing, 33/39 (85%) donors were initially positive for IgG antibodies, 31/39 (79%) for IgA, and 32/39 (82%) for IgM, while 27/39 (69%) were positive for all three isotypes. Persistence of IgG, IgA, and IgM was observed in 73%, 79%, and 32% of donors, respectively, after 6-9 months of observation. For IgM antibodies, the decline in the proportion of positive donors was statistically significant (p = 0.002) during 12 months observation, for IgG only the decline at 3 months was statistically significant (p = 0.042). Four donors exhibited notable increases in antibody levels. In conclusion, persistent SARS-CoV-2 IgA antibodies and IgG antibodies at 6-9 months are present in approximately three of four individuals with previous mild to moderate COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Donors / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Young adult Country/Region as subject: Europa Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27486

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Donors / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Young adult Country/Region as subject: Europa Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27486