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Successful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case report.
Daher, Ayham; Müller, Tobias; Spiesshoefer, Jens; Dreher, Michael; Panse, Jens.
  • Daher A; Department of Pneumology and Intensive Care Medicine, University Hospital RWTH, Aachen, Germany.
  • Müller T; Department of Pneumology and Intensive Care Medicine, University Hospital RWTH, Aachen, Germany.
  • Spiesshoefer J; Department of Pneumology and Intensive Care Medicine, University Hospital RWTH, Aachen, Germany.
  • Dreher M; Department of Pneumology and Intensive Care Medicine, University Hospital RWTH, Aachen, Germany.
  • Panse J; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH, Aachen, Germany.
Respir Med Case Rep ; 34: 101560, 2021.
Article in English | MEDLINE | ID: covidwho-1540946
ABSTRACT
A 71-year-old female patient with B-cell depletion due to treatment with an anti-CD20 monoclonal antibody was admitted for worsening COVID-19. Overall, she had persistent viral shedding, worsening respiratory failure, and progressive pneumonia that did not improve despite dexamethasone and antibiotic therapy. After administration of bamlanivimab, a monoclonal antibody with high affinity for the receptor-binding domain of the SARS-CoV-2 spike protein, inflammatory markers rapidly decreased, SARS-CoV2 RT-PCR became negative, and the patient improved clinically and radiologically. In conclusion, we demonstrated successful treatment of prolonged COVID-19 in a patient with severe B-cell aplasia with a virus-neutralizing monoclonal antibody.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Language: English Journal: Respir Med Case Rep Year: 2021 Document Type: Article Affiliation country: J.rmcr.2021.101560

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Language: English Journal: Respir Med Case Rep Year: 2021 Document Type: Article Affiliation country: J.rmcr.2021.101560