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Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies.
Zhong, Chaojie; Xia, Hongjie; Adam, Awadalkareem; Wang, Binbin; Hajnik, Renee L; Liang, Yuejin; Rafael, Grace H; Zou, Jing; Wang, Xiaofang; Sun, Jiaren; Soong, Lynn; Barrett, Alan D T; Weaver, Scott C; Shi, Pei-Yong; Wang, Tian; Hu, Haitao.
  • Zhong C; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Xia H; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Adam A; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Wang B; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Hajnik RL; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Liang Y; Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Rafael GH; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Zou J; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Wang X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Sun J; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Soong L; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Barrett ADT; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Weaver SC; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Shi PY; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Wang T; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Hu H; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, 77555, USA.
NPJ Vaccines ; 6(1): 139, 2021 Nov 29.
Article in English | MEDLINE | ID: covidwho-1541209
ABSTRACT
A candidate multigenic SARS-CoV-2 vaccine based on an MVA vector expressing both viral N and S proteins (MVA-S + N) was immunogenic, and induced T-cell responses and binding antibodies to both antigens but in the absence of detectable neutralizing antibodies. Intranasal immunization with the vaccine diminished viral loads and lung inflammation in mice after SARS-CoV-2 challenge, which correlated with the T-cell response induced by the vaccine in the lung, indicating that T-cell immunity is also likely critical for protection against SARS-CoV-2 infection in addition to neutralizing antibodies.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: NPJ Vaccines Year: 2021 Document Type: Article Affiliation country: S41541-021-00405-5

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: NPJ Vaccines Year: 2021 Document Type: Article Affiliation country: S41541-021-00405-5