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Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK).
Holt, Hayley; Talaei, Mohammad; Greenig, Matthew; Zenner, Dominik; Symons, Jane; Relton, Clare; Young, Katherine S; Davies, Molly R; Thompson, Katherine N; Ashman, Jed; Rajpoot, Sultan Saeed; Kayyale, Ahmed Ali; El Rifai, Sarah; Lloyd, Philippa J; Jolliffe, David; Timmis, Olivia; Finer, Sarah; Iliodromiti, Stamatina; Miners, Alec; Hopkinson, Nicholas S; Alam, Bodrul; Lloyd-Jones, Graham; Dietrich, Thomas; Chapple, Iain; Pfeffer, Paul E; McCoy, David; Davies, Gwyneth; Lyons, Ronan A; Griffiths, Christopher; Kee, Frank; Sheikh, Aziz; Breen, Gerome; Shaheen, Seif O; Martineau, Adrian R.
  • Holt H; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Talaei M; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Greenig M; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Zenner D; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Symons J; Jane Symons Media, London, UK.
  • Relton C; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Young KS; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Davies MR; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Thompson KN; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Ashman J; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Rajpoot SS; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Kayyale AA; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • El Rifai S; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Lloyd PJ; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Jolliffe D; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Timmis O; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Finer S; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Iliodromiti S; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Miners A; Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.
  • Hopkinson NS; National Heart and Lung Institute, Imperial College London, London, UK.
  • Alam B; Edenfield Road Surgery, Rochdale, UK.
  • Lloyd-Jones G; Department of Radiology, Salisbury District Hospital, Salisbury, UK.
  • Dietrich T; School of Dentistry, Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.
  • Chapple I; School of Dentistry, Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.
  • Pfeffer PE; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • McCoy D; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Davies G; Population Data Science, Swansea University Medical School, Swansea, UK.
  • Lyons RA; Population Data Science, Swansea University Medical School, Swansea, UK.
  • Griffiths C; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Kee F; Centre for Public Health Research (NI), Queen's University Belfast, Belfast, UK.
  • Sheikh A; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Breen G; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Shaheen SO; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Martineau AR; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK a.martineau@qmul.ac.uk.
Thorax ; 77(9): 900-912, 2022 09.
Article in English | MEDLINE | ID: covidwho-1541926
ABSTRACT

BACKGROUND:

Risk factors for severe COVID-19 include older age, male sex, obesity, black or Asian ethnicity and underlying medical conditions. Whether these factors also influence susceptibility to developing COVID-19 is uncertain.

METHODS:

We undertook a prospective, population-based cohort study (COVIDENCE UK) from 1 May 2020 to 5 February 2021. Baseline information on potential risk factors was captured by an online questionnaire. Monthly follow-up questionnaires captured incident COVID-19. We used logistic regression models to estimate multivariable-adjusted ORs (aORs) for associations between potential risk factors and odds of COVID-19.

RESULTS:

We recorded 446 incident cases of COVID-19 in 15 227 participants (2.9%). Increased odds of developing COVID-19 were independently associated with Asian/Asian British versus white ethnicity (aOR 2.28, 95% CI 1.33 to 3.91), household overcrowding (aOR per additional 0.5 people/bedroom 1.26, 1.11 to 1.43), any versus no visits to/from other households in previous week (aOR 1.31, 1.06 to 1.62), number of visits to indoor public places (aOR per extra visit per week 1.05, 1.02 to 1.09), frontline occupation excluding health/social care versus no frontline occupation (aOR 1.49, 1.12 to 1.98) and raised body mass index (BMI) (aOR 1.50 (1.19 to 1.89) for BMI 25.0-30.0 kg/m2 and 1.39 (1.06 to 1.84) for BMI >30.0 kg/m2 versus BMI <25.0 kg/m2). Atopic disease was independently associated with decreased odds (aOR 0.75, 0.59 to 0.97). No independent associations were seen for age, sex, other medical conditions, diet or micronutrient supplement use.

CONCLUSIONS:

After rigorous adjustment for factors influencing exposure to SARS-CoV-2, Asian/Asian British ethnicity and raised BMI were associated with increased odds of developing COVID-19, while atopic disease was associated with decreased odds. TRIAL REGISTRATION NUMBER ClinicalTrials.gov Registry (NCT04330599).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Limits: Humans / Male Country/Region as subject: Europa Language: English Journal: Thorax Year: 2022 Document Type: Article Affiliation country: Thoraxjnl-2021-217487

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Limits: Humans / Male Country/Region as subject: Europa Language: English Journal: Thorax Year: 2022 Document Type: Article Affiliation country: Thoraxjnl-2021-217487