Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot.
RNA
; 28(2): 239-249, 2022 02.
Article
in English
| MEDLINE | ID: covidwho-1542151
ABSTRACT
SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed -1 ribosomal frameshifting. The 1.3 Å-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. This structure represents a frameshift-stimulating state that must be deformed by the ribosome and exhibits base-triple-adjacent pockets that could be targeted by future small-molecule therapeutics.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA, Viral
/
Frameshifting, Ribosomal
/
SARS-CoV-2
/
Nucleic Acid Conformation
Language:
English
Journal:
RNA
Journal subject:
Molecular Biology
Year:
2022
Document Type:
Article
Affiliation country:
Rna.078825.121
Similar
MEDLINE
...
LILACS
LIS