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COVID-19 and Rheumatoid Arthritis Crosstalk: Emerging Association, Therapeutic Options and Challenges.
Dewanjee, Saikat; Kandimalla, Ramesh; Kalra, Rajkumar Singh; Valupadas, Chandrasekhar; Vallamkondu, Jayalakshmi; Kolli, Viswakalyan; Dey Ray, Sarbani; Reddy, Arubala P; Reddy, P Hemachandra.
  • Dewanjee S; Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur Unversity, Kolkata 700032, India.
  • Kandimalla R; Applied Biology, CSIR-Indian Institute of Technology, Uppal Road, Tarnaka, Hyderabad 50000, India.
  • Kalra RS; Department of Biochemistry, Kakatiya Medical College, Warangal 506007, India.
  • Valupadas C; AIST-INDIA DAILAB, National Institute of Advanced Industrial Science & Technology (AIST), Higashi 1-1-1, Tsukuba 305-8565, Japan.
  • Vallamkondu J; Department of Medicine, Mahatma Gandhi Memorial Hospital, Warangal 506007, India.
  • Kolli V; Department of Medicine, Kakatiya Medical College Superspeciality Hospital, Warangal 506007, India.
  • Dey Ray S; National Institute of Technology, Warangal 506004, India.
  • Reddy AP; Department of Biochemistry, GITAM Institute of Medical Sciences and Research, Visakhapatnam 530045, India.
  • Reddy PH; Department of Pharmaceutical Sciences, Assam University, Silchar 788011, India.
Cells ; 10(12)2021 11 24.
Article in English | MEDLINE | ID: covidwho-1542427
ABSTRACT
Hyperactivation of immune responses resulting in excessive release of pro-inflammatory mediators in alveoli/lung structures is the principal pathological feature of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The cytokine hyperactivation in COVID-19 appears to be similar to those seen in rheumatoid arthritis (RA), an autoimmune disease. Emerging evidence conferred the severity and risk of COVID-19 to RA patients. Amid the evidence of musculoskeletal manifestations involving immune-inflammation-dependent mechanisms and cases of arthralgia and/or myalgia in COVID-19, crosstalk between COVID-19 and RA is often debated. The present article sheds light on the pathological crosstalk between COVID-19 and RA, the risk of RA patients in acquiring SARS-CoV-2 infection, and the aspects of SARS-CoV-2 infection in RA development. We also conferred whether RA can exacerbate COVID-19 outcomes based on available clinical readouts. The mechanistic overlapping in immune-inflammatory features in both COVID-19 and RA was discussed. We showed the emerging links of angiotensin-converting enzyme (ACE)-dependent and macrophage-mediated pathways in both diseases. Moreover, a detailed review of immediate challenges and key recommendations for anti-rheumatic drugs in the COVID-19 setting was presented for better clinical monitoring and management of RA patients. Taken together, the present article summarizes available knowledge on the emerging COVID-19 and RA crosstalk and their mechanistic overlaps, challenges, and therapeutic options.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10123291

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10123291