Skin Aging, Cellular Senescence and Natural Polyphenols.
Int J Mol Sci
; 22(23)2021 Nov 23.
Article
in English
| MEDLINE | ID: covidwho-1542580
ABSTRACT
The skin, being the barrier organ of the body, is constitutively exposed to various stimuli impacting its morphology and function. Senescent cells have been found to accumulate with age and may contribute to age-related skin changes and pathologies. Natural polyphenols exert many health benefits, including ameliorative effects on skin aging. By affecting molecular pathways of senescence, polyphenols are able to prevent or delay the senescence formation and, consequently, avoid or ameliorate aging and age-associated pathologies of the skin. This review aims to provide an overview of the current state of knowledge in skin aging and cellular senescence, and to summarize the recent in vitro studies related to the anti-senescent mechanisms of natural polyphenols carried out on keratinocytes, melanocytes and fibroblasts. Aged skin in the context of the COVID-19 pandemic will be also discussed.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Skin Aging
/
Cellular Senescence
/
Polyphenols
Limits:
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Ijms222312641
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