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Norovirus: Facts and Reflections from Past, Present, and Future.
Lucero, Yalda; Matson, David O; Ashkenazi, Shai; George, Sergio; O'Ryan, Miguel.
  • Lucero Y; Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.
  • Matson DO; Hospital Dr. Roberto del Río Hospital, Department of Pediatrics and Pediatric Surgery (Northern Campus), Faculty of Medicine, Universidad de Chile, Santiago 8380418, Chile.
  • Ashkenazi S; Clínica Alemana de Santiago, Faculty of Medicine, Universidad del Desarrollo-Clínica Alemana, Santiago 7650568, Chile.
  • George S; Eastern Shore Health Department, Virginia Department of Public Health, Accomack County, VA 23301, USA.
  • O'Ryan M; Adelson School of Medicine, Ariel University, Ariel 40700, Israel.
Viruses ; 13(12)2021 11 30.
Article in English | MEDLINE | ID: covidwho-1542802
ABSTRACT
Human Norovirus is currently the main viral cause of acute gastroenteritis (AGEs) in most countries worldwide. Nearly 50 years after the discovery of the "Norwalk virus" by Kapikian and colleagues, the scientific and medical community continue to generate new knowledge on the full biological and disease spectrum of Norovirus infection. Nevertheless, several areas remain incompletely understood due to the serious constraints to effectively replicate and propagate the virus. Here, we present a narrated historic perspective and summarize our current knowledge, including insights and reflections on current points of interest for a broad medical community, including clinical and molecular epidemiology, viral-host-microbiota interactions, antivirals, and vaccine prototypes. We also include a reflection on the present and future impacts of the COVID-19 pandemic on Norovirus infection and disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Caliciviridae Infections / Norovirus / Gastroenteritis Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13122399

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Caliciviridae Infections / Norovirus / Gastroenteritis Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13122399