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Use of remdesivir in children with COVID-19 infection: a quick narrative review.
La Tessa, Andrea; Motisi, Marco Antonio; Marseglia, Gian Luigi; Cardinale, Fabio; Licari, Amelia; Manti, Sara; Tosca, Mariangela; Del Giudice, Michele Miraglia; De Filippo, Maria; Galli, Luisa; Chiappini, Elena.
  • La Tessa A; Department of Pediatric Infectious Disease, Anna Meyer Children's Hospital, Firenze, Italy. elena.chiappini@unifi.it.
  • Motisi MA; Department of Pediatric Infectious Disease, Anna Meyer Children's Hospital, Firenze, Italy. elena.chiappini@unifi.it.
  • Marseglia GL; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. elena.chiappini@unifi.it.
  • Cardinale F; Department of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy. elena.chiappini@unifi.it.
  • Licari A; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. elena.chiappini@unifi.it.
  • Manti S; Department of Clinical and Experimental Medicine, Pediatric Respiratory Unit, San Marco Hospital, University of Catania, Catania, Italy. elena.chiappini@unifi.it.
  • Tosca M; Allergy Centre, IRCCS G. Gaslini Pediatric Hospital, Genova, Italy. elena.chiappini@unifi.it.
  • Del Giudice MM; Department of Woman, Child and of General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', Naples, Italy. elena.chiappini@unifi.it.
  • De Filippo M; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy. elena.chiappini@unifi.it.
  • Galli L; Department of Pediatric Infectious Disease, Anna Meyer Children's Hospital, Firenze, Italy. elena.chiappini@unifi.it.
  • Chiappini E; Division of Paediatric Infectious Disease, Anna Meyer Children's University Hospital, Department of Health Sciences, University of Florence, Florence, Italy.. elena.chiappini@unifi.it.
Acta Biomed ; 92(S7): e2021524, 2021 11 29.
Article in English | MEDLINE | ID: covidwho-1543088
ABSTRACT
SARS-CoV-2 infection has a severe course in a small percentage of children. Remdesivir has shown promising results in reducing hospitalisation time in adults, but data on mortality rate are conflicting and few studies are available on its use use in antivirals in children. We performed a quick narrative review of the available literature data regarding the usage of remdesivir in children and neonates. In children, remdesivir showed good safety profile, however bradicardia events have been reported in children. Remdesivir is currently recommended by several guidelines in some subgroups of children with severe COVID-19, and should also be considered in critically ill patients, always in the context of the overall clinical picture and drug availability.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment Type of study: Prognostic study / Reviews Limits: Adult / Child / Humans / Infant, Newborn Language: English Journal: Acta Biomed Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Abm.v92iS7.12396

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment Type of study: Prognostic study / Reviews Limits: Adult / Child / Humans / Infant, Newborn Language: English Journal: Acta Biomed Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Abm.v92iS7.12396