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Prevalence and clinical outcomes of pleural effusion in COVID-19 patients: A systematic review and meta-analysis.
Rathore, Sawai Singh; Hussain, Nabeel; Manju, Ade Harrison; Wen, Qingqing; Tousif, Sohaib; Avendaño-Capriles, Camilo Andrés; Hernandez-Woodbine, Maria Jose; Rojas, Gianpier Alonzo; Vatsavayi, Priyanka; Tera, Chenna Reddy; Ali, Muhammad Adnan; Singh, Romil; Saleemi, Shayan; Patel, Deep Manojkumar.
  • Rathore SS; Dr. Sampurnanand Medical College, Jodhpur, Rajasthan, India.
  • Hussain N; Saba University School of Medicine, The Bottom, The Netherlands.
  • Manju AH; Clinical Pathology, Faculty of Biochemical Science, University of Yaounde I, Yaounde, Cameroon.
  • Wen Q; University of California Los Angeles, Fielding School of Public Health, Los Angeles, California, USA.
  • Tousif S; Ziauddin Medical university, Karachi, Pakistan.
  • Avendaño-Capriles CA; Universidad del Norte, Barranquilla, Colombia.
  • Hernandez-Woodbine MJ; Universidad del Norte, Barranquilla, Colombia.
  • Rojas GA; School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Vatsavayi P; Kamineni Institute of Medical Sciences, Nalgonda, Telangana, India.
  • Tera CR; Kamineni Institute of Medical Sciences, Nalgonda, Telangana, India.
  • Ali MA; Jinnah Sindh Medical University, Karachi, Pakistan.
  • Singh R; Department of Critical Care, Mayo Clinic, Rochester, Minnesota, USA.
  • Saleemi S; Department of Pulmonology, Aga Khan University Hospital, Karachi, Pakistan.
  • Patel DM; Our Lady of Fatima University College of Medicine, Valenzuela City, Philippines.
J Med Virol ; 94(1): 229-239, 2022 01.
Article in English | MEDLINE | ID: covidwho-1544339
ABSTRACT
Observational studies indicate that pleural effusion has an association with risk and the clinical prognosis of COVID-19 disease; however, the available literature on this area is inconsistent. The objective of this systematic review and meta-analysis is to evaluate the correlation between COVID-19 disease and pleural effusion. A rigorous literature search was conducted using multiple databases. All eligible observational studies were included from around the globe. The pooled prevalence and associated 95% confidence interval (CI) were calculated using the random effect model. Mantel-Haenszel odds ratios were produced to report overall effect size using random effect models for severity and mortality outcomes. Funnel plots, Egger regression tests, and Begg-Mazumdar's rank correlation test were used to appraise publication bias. Data from 23 studies including 6234 COVID-19 patients was obtained. The overall prevalence of pleural effusion in COVID-19 patients was 9.55% (95% CI, I2 = 92%). Our findings also indicated that the presence of pleural effusions associated with increased risk of severity of disease(OR = 5.08, 95% CI 3.14-8.22, I2 = 77.4%) and mortality due to illness(OR = 4.53, 95% CI 2.16-9.49, I2 = 66%) compared with patients without pleural effusion. Sensitivity analyses illustrated a similar effect size while decreasing the heterogeneity. No significant publication bias was evident in the meta-analysis. The presence of pleural effusion can assist as a prognostic factor to evaluate the risk of worse outcomes in COVID-19 patients hence, it is recommended that hospitalized COVID-19 patients with pleural effusion should be managed on an early basis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pleural Effusion / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27301

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pleural Effusion / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27301