Severity of SARS-CoV-2 infection is linked to double-negative (CD27- IgD-) B cell subset numbers.
Inflamm Res
; 71(1): 131-140, 2022 Jan.
Article
in English
| MEDLINE | ID: covidwho-1544398
ABSTRACT
OBJECTIVES:
The role of B cells in COVID-19, beyond the production of specific antibodies against SARS-CoV-2, is still not well understood. Here, we describe the novel landscape of circulating double-negative (DN) CD27- IgD- B cells in COVID-19 patients, representing a group of atypical and neglected subpopulations of this cell lineage.METHODS:
Using multiparametric flow cytometry, we determined DN B cell subset amounts from 91 COVID-19 patients, correlated those with cytokines, clinical and laboratory parameters, and segregated them by principal components analysis.RESULTS:
We detected significant increments in the DN2 and DN3 B cell subsets, while we found a relevant decrease in the DN1 B cell subpopulation, according to disease severity and patient outcomes. These DN cell numbers also appeared to correlate with pro- or anti-inflammatory signatures, respectively, and contributed to the segregation of the patients into disease severity groups.CONCLUSION:
This study provides insights into DN B cell subsets' potential role in immune responses against SARS-CoV-2, particularly linked to the severity of COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Immunoglobulin D
/
Tumor Necrosis Factor Receptor Superfamily, Member 7
/
SARS-CoV-2
/
COVID-19
Type of study:
Diagnostic study
/
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Language:
English
Journal:
Inflamm Res
Journal subject:
Allergy and Immunology
/
Pathology
Year:
2022
Document Type:
Article
Affiliation country:
S00011-021-01525-3
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