Secretome of Mesenchymal Bone Marrow Stem Cells: Is It Immunosuppressive or Proinflammatory?
Bull Exp Biol Med
; 172(2): 250-253, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1544492
ABSTRACT
Mesenchymal stem cells (MSC) are characterized by tolerogenic potential and therefore, are used in the treatment of autoimmune diseases such as graft-versus-host disease (GVHD) reactions after allogeneic hematopoietic cell transplantation to improve the transplant functions, as well as for the therapy and prevention of cytokine storm in COVID-19 patients and some other conditions. However, MSC can exhibit proinflammatory activity, which causes risks for their clinical use. We studied the cytokine profile of bone marrow MSC culture and demonstrate intensive production of IL-6, IL-8, and chemokine MCP-1, which participate in the pathogenesis of cytokine storm and GVHD. At the same time, no anti-inflammatory IL-4 and IL-10 were detected. To reduce the risks of MSC application in the GVHD therapeutic protocols, further studies of the conditions promoting generation of MSC with tolerogenic potential and approved clinical standards of MSC use are required.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cytokines
/
Mesenchymal Stem Cell Transplantation
/
Mesenchymal Stem Cells
/
Cytokine Release Syndrome
/
COVID-19
/
Graft vs Host Disease
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Bull Exp Biol Med
Year:
2021
Document Type:
Article
Affiliation country:
S10517-021-05371-5
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