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Myocarditis and pericarditis in adolescents after first and second doses of mRNA COVID-19 vaccines.
Foltran, Déborah; Delmas, Clément; Flumian, Clara; De Paoli, Pierre; Salvo, Francesco; Gautier, Sophie; Drici, Milou-Daniel; Karsenty, Clément; Montastruc, François.
  • Foltran D; Department of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and Pharmacoepidemiology, Faculty of Medicine, Toulouse University Hospital (CHU), 37 Allées Jules Guesde, F-31000 Toulouse, France.
  • Delmas C; Team PEPSS (Pharmacologie En Population cohorteS et biobanqueS), Centre d'Investigation Clinique 1436, Toulouse University Hospital, France.
  • Flumian C; Department of Cardiology, Faculty of Medicine, Toulouse University Hospital (CHU), Toulouse, France.
  • De Paoli P; Department of Cardiology, Faculty of Medicine, Toulouse University Hospital (CHU), Toulouse, France.
  • Salvo F; Department of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and Pharmacoepidemiology, Faculty of Medicine, Toulouse University Hospital (CHU), 37 Allées Jules Guesde, F-31000 Toulouse, France.
  • Gautier S; Team PEPSS (Pharmacologie En Population cohorteS et biobanqueS), Centre d'Investigation Clinique 1436, Toulouse University Hospital, France.
  • Drici MD; Department of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and Pharmacoepidemiology, Faculty of Medicine, Toulouse University Hospital (CHU), 37 Allées Jules Guesde, F-31000 Toulouse, France.
  • Karsenty C; INSERM U1219, Bordeaux Population Health, Team Pharmacoepidemiology, University of Bordeaux, F-33000 Bordeaux, France.
  • Montastruc F; Medical Pharmacology Unit, Public Health Division, Bordeaux University Hospital (CHU), F-33000 Bordeaux, France.
Eur Heart J Qual Care Clin Outcomes ; 8(2): 99-103, 2022 03 02.
Article in English | MEDLINE | ID: covidwho-1545925
ABSTRACT

AIMS:

While some concerns about vaccination-related pericarditis and/or myocarditis have been raised, no published data are available on pericarditis and/or myocarditis with mRNA COVID-19 vaccines in the age group of adolescents, particularly 12-15 years. The objective of this study was to determine whether the risk of reporting pericarditis and/or myocarditis with mRNA COVID-19 vaccines varied according to dose of vaccination, age, sex, and type of pericarditis and/or myocarditis in adolescents between 12 and 17 years. METHODS AND

RESULTS:

We performed an observational study reviewing all reports of adolescents vaccinated with mRNA COVID-19 vaccines and recorded in VigiBase®, the World Health Organization global database of individual case safety reports. We included all reports registered between 1 January 2021 and 14 September 2021. Reporting odds ratios (RORs) with their 95% confidence interval (CI) were calculated to estimate the risk of reporting pericarditis and/or myocarditis. Among 4942 reports with mRNA COVID-19 vaccines in adolescents, we identified 242 pericarditis and/or myocarditis. Compared with the first dose of mRNA COVID-19 vaccines, the second dose was associated with an increased risk of reporting pericarditis and/or myocarditis (ROR 4.95; 95% CI 3.14, 7.89). The risk of reporting pericarditis and/or myocarditis was 10 times higher in boys than in girls and no difference between the two types of vaccines could be demonstrated.

CONCLUSION:

This investigation including only adolescent data suggests for the first time that the second dose of mRNA COVID-19 vaccines increases the risk of reporting myocarditis/pericarditis compared with the first dose particularly in boys without significant difference between tozinameran and elasomeran.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pericarditis / COVID-19 / Myocarditis Type of study: Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adolescent / Child / Female / Humans / Male Language: English Journal: Eur Heart J Qual Care Clin Outcomes Year: 2022 Document Type: Article Affiliation country: Ehjqcco

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pericarditis / COVID-19 / Myocarditis Type of study: Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adolescent / Child / Female / Humans / Male Language: English Journal: Eur Heart J Qual Care Clin Outcomes Year: 2022 Document Type: Article Affiliation country: Ehjqcco