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Autochthonous West Nile virus infection in Germany: Increasing numbers and a rare encephalitis case in a kidney transplant recipient.
Schneider, Julia; Bachmann, Friederike; Choi, Mira; Kurvits, Lille; Schmidt, Marie Luisa; Bergfeld, Leon; Meier, Iris; Zuchowski, Marta; Werber, Dirk; Hofmann, Jörg; Ruprecht, Klemens; Eckardt, Kai-Uwe; Jones, Terry C; Drosten, Christian; Corman, Victor Max.
  • Schneider J; Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Bachmann F; German Centre for Infection Research (DZIF), Berlin, Germany.
  • Choi M; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Kurvits L; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Schmidt ML; Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Bergfeld L; Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Meier I; Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Zuchowski M; State Office for Health and Social Affairs, Berlin, Germany.
  • Werber D; Labor Berlin-Charité Vivantes GmbH, Berlin, Germany.
  • Hofmann J; State Office for Health and Social Affairs, Berlin, Germany.
  • Ruprecht K; Labor Berlin-Charité Vivantes GmbH, Berlin, Germany.
  • Eckardt KU; Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Jones TC; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Drosten C; Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Corman VM; German Centre for Infection Research (DZIF), Berlin, Germany.
Transbound Emerg Dis ; 69(2): 221-226, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1546411
ABSTRACT
West Nile Virus (WNV) infections are increasingly detected in birds and horses in central Europe, with the first mosquito-borne autochthonous human infection detected in Germany in 2019. Human infections are typically asymptomatic, with occasional severe neurological disease. Because of a low number of cases in central Europe, awareness regarding potential cases is low and WNV diagnostic testing is not routine. We tested cerebrospinal fluid (CSF) samples from unsolved encephalitis and meningitis cases from Berlin from 2019 to 2020, and describe a WNV-encephalitis case in a 33-year-old kidney transplant recipient. The infectious course was resolved by serology, RT-PCR and sequencing of stored samples. Phylogenetic sequence analysis revealed a close relationship of the patient's WNV strain to German sequences from 2019 and 2020. A lack of travel history and patient self-isolation during the SARS-CoV-2 pandemic suggest the infection was acquired in the patient's home or garden. Serological tests of four people sharing the living space were negative. Retrospective RT-PCR and WNV-IgM testing of 671 CSF samples from unsolved encephalitis and meningitis cases from Berlin detected no additional infections. The recent increase of WNV cases illustrates the importance of considering WNV in cases of meningoencephalitis, especially in immunocompromised patients, as described here. Proper education and communication and a revised diagnostic strategy will help to raise awareness and to detect future WNV infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: West Nile Fever / West Nile virus / Kidney Transplantation Type of study: Diagnostic study Limits: Adult / Humans Language: English Journal: Transbound Emerg Dis Journal subject: Veterinary Medicine Year: 2022 Document Type: Article Affiliation country: Tbed.14406

Full text: Available Collection: International databases Database: MEDLINE Main subject: West Nile Fever / West Nile virus / Kidney Transplantation Type of study: Diagnostic study Limits: Adult / Humans Language: English Journal: Transbound Emerg Dis Journal subject: Veterinary Medicine Year: 2022 Document Type: Article Affiliation country: Tbed.14406