Your browser doesn't support javascript.
Rare, disseminated Kaposi sarcoma in advanced HIV with high-burden pulmonary and skeletal involvement.
Connolly, Stephen P; McGrath, Jonathan; Sui, Jane; Muldoon, Eavan G.
  • Connolly SP; Department of Infectious Diseases, Mater Misericordiae University Hospital, Dublin, Ireland sconnolly91@gmail.com.
  • McGrath J; School of Medicine, University College Dublin, Dublin, Dublin, Ireland.
  • Sui J; Department of Infectious Diseases, Mater Misericordiae University Hospital, Dublin, Ireland.
  • Muldoon EG; Department of Medical Oncology, Mater Misericordiae University Hospital, Dublin, Ireland.
BMJ Case Rep ; 14(12)2021 Dec 01.
Article in English | MEDLINE | ID: covidwho-1546476
ABSTRACT
We describe the case of a 30-year-old man who presented to our institution with hypoxia and widespread pulmonary infiltrates managed initially as COVID-19 before receiving a new diagnosis of HIV-associated Kaposi sarcoma (KS) with widespread pulmonary and skeletal involvement. Initial differential diagnoses included Pneumocystis jirovecii pneumonia, disseminated mycobacterial infection and bacillary angiomatosis. A bone marrow biopsy showed heavy infiltration by spindle cells, staining strongly positive for human herpes virus-8 (HHV-8) and CD34, suggesting symptomatic, disseminated KS as the unifying diagnosis. The patient commenced cytotoxic therapy with weekly paclitaxel, with a clinical and radiological response. To our knowledge, this case is among the most severe described in the literature, which we discuss, along with how COVID-19 initially hindered developing a therapeutic allegiance with the patient.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Sarcoma, Kaposi / HIV Infections / Herpesvirus 8, Human / COVID-19 Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid Limits: Adult / Humans / Male Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2021-245448

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Sarcoma, Kaposi / HIV Infections / Herpesvirus 8, Human / COVID-19 Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid Limits: Adult / Humans / Male Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2021-245448