IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis.
J Immunol Res
; 2021: 8214656, 2021.
Article
in English
| MEDLINE | ID: covidwho-1546598
ABSTRACT
Dengue fever is an infection by the dengue virus (DENV) transmitted by vector mosquitoes. It causes many infections in tropical and subtropical countries every year, thus posing a severe disease threat. Cytokine storms, one condition where many proinflammatory cytokines are mass-produced, might lead to cellular dysfunction in tissue/organ failures and often facilitate severe dengue disease in patients. Interleukin- (IL-) 18, similar to IL-1ß, is a proinflammatory cytokine produced during inflammation following inflammasome activation. Inflammatory stimuli, including microbial infections, damage signals, and cytokines, all induce the production of IL-18. High serum IL-18 is remarkably correlated with severely ill dengue patients; however, its possible roles have been less explored. Based on the clinical and basic findings, this review discusses the potential immunopathogenic role of IL-18 when it participates in DENV infection and dengue disease progression based on existing findings and related past studies.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Interleukin-18
/
Dengue
/
Dengue Virus
/
Inflammasomes
/
Inflammation
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
J Immunol Res
Year:
2021
Document Type:
Article
Affiliation country:
2021
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