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SARS-CoV-2 productively infects human gut enterocytes.
Lamers, Mart M; Beumer, Joep; van der Vaart, Jelte; Knoops, Kèvin; Puschhof, Jens; Breugem, Tim I; Ravelli, Raimond B G; Paul van Schayck, J; Mykytyn, Anna Z; Duimel, Hans Q; van Donselaar, Elly; Riesebosch, Samra; Kuijpers, Helma J H; Schipper, Debby; van de Wetering, Willine J; de Graaf, Miranda; Koopmans, Marion; Cuppen, Edwin; Peters, Peter J; Haagmans, Bart L; Clevers, Hans.
  • Lamers MM; Viroscience Department, Erasmus Medical Center, Rotterdam, Netherlands.
  • Beumer J; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, Netherlands.
  • van der Vaart J; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, Netherlands.
  • Knoops K; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.
  • Puschhof J; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, Netherlands.
  • Breugem TI; Viroscience Department, Erasmus Medical Center, Rotterdam, Netherlands.
  • Ravelli RBG; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.
  • Paul van Schayck J; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.
  • Mykytyn AZ; Viroscience Department, Erasmus Medical Center, Rotterdam, Netherlands.
  • Duimel HQ; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.
  • van Donselaar E; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.
  • Riesebosch S; Viroscience Department, Erasmus Medical Center, Rotterdam, Netherlands.
  • Kuijpers HJH; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.
  • Schipper D; Viroscience Department, Erasmus Medical Center, Rotterdam, Netherlands.
  • van de Wetering WJ; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.
  • de Graaf M; Viroscience Department, Erasmus Medical Center, Rotterdam, Netherlands.
  • Koopmans M; Viroscience Department, Erasmus Medical Center, Rotterdam, Netherlands.
  • Cuppen E; Center for Molecular Medicine and Oncode Institute, University Medical Centre Utrecht, Utrecht, Netherlands.
  • Peters PJ; Hartwig Medical Foundation, Amsterdam, Netherlands.
  • Haagmans BL; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, Netherlands.
  • Clevers H; Viroscience Department, Erasmus Medical Center, Rotterdam, Netherlands.
Science ; 369(6499): 50-54, 2020 07 03.
Article in English | MEDLINE | ID: covidwho-154670
Preprint
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ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission through the respiratory route. However, clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids (hSIOs), enterocytes were readily infected by SARS-CoV and SARS-CoV-2, as demonstrated by confocal and electron microscopy. Enterocytes produced infectious viral particles, whereas messenger RNA expression analysis of hSIOs revealed induction of a generic viral response program. Therefore, the intestinal epithelium supports SARS-CoV-2 replication, and hSIOs serve as an experimental model for coronavirus infection and biology.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / Enterocytes / Betacoronavirus / Ileum Type of study: Prognostic study Limits: Humans / Male Language: English Journal: Science Year: 2020 Document Type: Article Affiliation country: Science.abc1669

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / Enterocytes / Betacoronavirus / Ileum Type of study: Prognostic study Limits: Humans / Male Language: English Journal: Science Year: 2020 Document Type: Article Affiliation country: Science.abc1669