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Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study.
Mohamed Ali, Sameera; Musa, Anas; Omar Muhammed, Khalifa; Javed, Sumbul; Al Raqabani, Mohamed; Adnan Baradie, Basem; Sobhi Gargousa, Marian; Osman, Oghowan AbdelRahman; AlDeen Roqia, Salah; Lakshmanan, Jeyaseelan; Al Hashemi, Haitham; Omar Baslaib, Fahad.
  • Mohamed Ali S; Rashid Hospital, Dubai, U.A.E.
  • Musa A; Rashid Hospital, Dubai, U.A.E.
  • Omar Muhammed K; Rashid Hospital, Dubai, U.A.E.
  • Javed S; Rashid Hospital, Dubai, U.A.E.
  • Al Raqabani M; Rashid Hospital, Dubai, U.A.E.
  • Adnan Baradie B; Rashid Hospital, Dubai, U.A.E.
  • Sobhi Gargousa M; Rashid Hospital, Dubai, U.A.E.
  • Osman OA; Rashid Hospital, Dubai, U.A.E.
  • AlDeen Roqia S; Rashid Hospital, Dubai, U.A.E.
  • Lakshmanan J; Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, U.A.E.
  • Al Hashemi H; Rashid Hospital, Dubai, U.A.E.
  • Omar Baslaib F; Rashid Hospital, Dubai, U.A.E.
J Int Med Res ; 49(11): 3000605211056834, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1546700
ABSTRACT

OBJECTIVE:

To evaluate the association of a prolonged corrected QT (QTc) interval in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its association with in-patient mortality.

METHODS:

A cohort of 745 patients were recruited from a single center between 1 March 2020 and 31 May 2020. We analyzed the factors associated with a prolonged QTc and mortality.

RESULTS:

A prolonged QTc interval >450 ms was found in 27% of patients admitted with SARS-CoV-2 infection. These patients were predominantly older, on a ventilator, and had hypertension, diabetes mellitus, or ischemic heart disease. They also had high troponin and D-dimer concentrations. A prolonged QTc interval had a significant association with the requirement of ventilator support and was associated with an increased odds of mortality. Patients who died were older than 55 years, and had high troponin, D-dimer, creatinine, procalcitonin, and ferritin concentrations, a high white blood cell count, and abnormal potassium concentrations (hypo- or hyperkalemia).

CONCLUSIONS:

A prolonged QTc interval is common in patients with SARS-CoV-2 infection and it is associated with worse outcomes. Older individuals and those with comorbidities should have an electrocardiogram performed, which is noninvasive and easily available, on admission to hospital to identify high-risk patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Long QT Syndrome / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Country/Region as subject: Asia Language: English Journal: J Int Med Res Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Long QT Syndrome / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Country/Region as subject: Asia Language: English Journal: J Int Med Res Year: 2021 Document Type: Article