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Discrepant Antigen-specific Antibody Responses Causing SARS-CoV-2 Persistence in a Patient Receiving B-cell-targeted Therapy with Rituximab.
Takakuwa, Teruhito; Nakagama, Yu; Yasugi, Mayo; Maeda, Toshiki; Matsuo, Kenji; Kiritoshi, Ayako; Deguchi, Ryo; Hagawa, Naohiro; Shibata, Wataru; Oshima, Kazuhiro; Yamamoto, Katsumi; Uchida, Kenichiro; Noda, Tomohiro; Yamada, Koichi; Nishimura, Tetsuro; Yamamoto, Hiromasa; Kido, Yasutoshi; Hino, Masayuki; Kakeya, Hiroshi; Mizobata, Yasumitsu.
  • Takakuwa T; Department of Hematology, Graduate School of Medicine, Osaka City University, Japan.
  • Nakagama Y; Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City University, Japan.
  • Yasugi M; Department of Veterinary Medicine, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan.
  • Maeda T; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan.
  • Matsuo K; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan.
  • Kiritoshi A; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan.
  • Deguchi R; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan.
  • Hagawa N; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan.
  • Shibata W; Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan.
  • Oshima K; Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan.
  • Yamamoto K; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan.
  • Uchida K; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan.
  • Noda T; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan.
  • Yamada K; Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan.
  • Nishimura T; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan.
  • Yamamoto H; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan.
  • Kido Y; Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City University, Japan.
  • Hino M; Department of Hematology, Graduate School of Medicine, Osaka City University, Japan.
  • Kakeya H; Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan.
  • Mizobata Y; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Japan.
Intern Med ; 60(23): 3827-3831, 2021.
Article in English | MEDLINE | ID: covidwho-1547076
ABSTRACT
A 73-year-old man previously treated with rituximab for his mucosa-associated lymphoid tissue lymphoma suffered a suboptimal humoral immune response against an acquired SARS-CoV-2 infection. A detailed serological description revealed discrepant antigen-specific humoral immune responses. The titer of spike-targeting, "viral-neutralizing" antibodies remained below the detection level, in contrast to the anti-nucleocapsid, "binding" antibody response, which was comparable in both magnitude and kinetics. Accordingly, viral neutralizability and clearance was delayed, leading to prolonged RNAemia and persistent pneumonia. The present case highlights the need to closely monitor this unique population of recipients of B-cell-targeted therapies for their neutralizing antibody responses against SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Case report Limits: Aged / Humans / Male Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: Internalmedicine.7884-21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Case report Limits: Aged / Humans / Male Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: Internalmedicine.7884-21