Your browser doesn't support javascript.
Convalescent plasma transfusion for the treatment of COVID-19: Systematic review.
Rajendran, Karthick; Krishnasamy, Narayanasamy; Rangarajan, Jayanthi; Rathinam, Jeyalalitha; Natarajan, Murugan; Ramachandran, Arunkumar.
  • Rajendran K; Multidisciplinary Research Unit (MRU), Madras Medical College, Chennai, Tamil Nadu, India.
  • Krishnasamy N; Madras Medical College, Institute of Hepatobiliary Sciences, Chennai, Tamil Nadu, India.
  • Rangarajan J; Institute of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India.
  • Rathinam J; Institute of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India.
  • Natarajan M; Institute of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India.
  • Ramachandran A; Multidisciplinary Research Unit (MRU), Madras Medical College, Chennai, Tamil Nadu, India.
J Med Virol ; 92(9): 1475-1483, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-154818
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
3. Persons LOCATION_OF Plasma
Subject
Persons
Predicate
LOCATION_OF
Object
Plasma
4. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
5. Patients LOCATION_OF Plasma
Subject
Patients
Predicate
LOCATION_OF
Object
Plasma
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
8. Persons LOCATION_OF Plasma
Subject
Persons
Predicate
LOCATION_OF
Object
Plasma
9. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
10. Patients LOCATION_OF Plasma
Subject
Patients
Predicate
LOCATION_OF
Object
Plasma
ABSTRACT
The recent emergence of coronavirus disease 2019 (COVID-19) pandemic has reassessed the usefulness of historic convalescent plasma transfusion (CPT). This review was conducted to evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date. To our knowledge, this is the first systematic review on convalescent plasma on clinically relevant outcomes in individuals with COVID-19. PubMed, EMBASE, and Medline databases were searched upto 19 April 2020. All records were screened as per the protocol eligibility criteria. We included five studies reporting CPT to COVID-19 patients. The main findings from available data are as follows (a) Convalescent plasma may reduce mortality in critically ill patients, (b) Increase in neutralizing antibody titers and disappearance of SARS-CoV-2 RNA was observed in almost all the patients after CPT therapy, and (c) Beneficial effect on clinical symptoms after administration of convalescent plasma. Based on the limited scientific data, CPT therapy in COVID-19 patients appears safe, clinically effective, and reduces mortality. Well-designed large multicenter clinical trial studies should be conducted urgently to establish the efficacy of CPT to COVID-19 patients.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: COVID-19 Subject: COVID-19 Type of study: Systematic review Language: English Journal: J Med Virol Year: 2020

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: COVID-19 Subject: COVID-19 Type of study: Systematic review Language: English Journal: J Med Virol Year: 2020
...