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Anti-SARS-CoV-2 Inhibitory Profile of New Quinoline Compounds in Cell Culture-Based Infection Models.
Herrmann, Lars; Hahn, Friedrich; Wangen, Christina; Marschall, Manfred; Tsogoeva, Svetlana B.
  • Herrmann L; Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen-Nürnberg, Nikolaus Fiebiger-Straße 10, 91058, Erlangen, Germany.
  • Hahn F; Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054, Erlangen, Germany.
  • Wangen C; Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054, Erlangen, Germany.
  • Marschall M; Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054, Erlangen, Germany.
  • Tsogoeva SB; Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen-Nürnberg, Nikolaus Fiebiger-Straße 10, 91058, Erlangen, Germany.
Chemistry ; 28(4): e202103861, 2022 Jan 19.
Article in English | MEDLINE | ID: covidwho-1549185
ABSTRACT
The presently ongoing pandemic of human SARS-CoV-2 infections (COVID-19) presents an enormous challenge in surveillance, vaccine and antiviral drug development. Here we report the synthesis of new bioactive quinoline-morpholine hybrid compounds and their virological evaluation, which proves pronounced cell culture-based inhibitory profile against SARS-CoV-2. Thus, selected quinoline compounds may suggest specific hit-to-lead development.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Quinolines / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Chemistry Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: Chem.202103861

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Quinolines / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Chemistry Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: Chem.202103861