Strategies for drug repurposing against coronavirus targets.
Curr Res Pharmacol Drug Discov
; 3: 100072, 2022.
Article
in English
| MEDLINE | ID: covidwho-1549725
ABSTRACT
Repurposing regulatory agency approved drugs and investigational compounds with known safety profiles can significantly fast track the drug development timeline over de novo drug discovery, with lower investment requirements and improved attrition rate. These advantages are vital in any epidemic or pandemic situation, where hospital beds are occupied by patients for whom there is no known treatment. Here we examine drug repurposing in the context of human coronaviruses, SARS-CoV, MERS-CoV, and, in particular, SARS-CoV-2, the virus currently causing a continued widespread pandemic with substantial impacts on public health and economy. The key druggable targets explored were those involved in viral entry, viral replication, and viral-induced ARDS, as well as viral proteases, with a focus on the strategy by which the drugs were repurposed.
Full text:
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Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Curr Res Pharmacol Drug Discov
Year:
2022
Document Type:
Article
Affiliation country:
J.crphar.2021.100072
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