How integrin phosphorylations regulate cell adhesion and signaling.
Trends Biochem Sci
; 47(3): 265-278, 2022 03.
Article
in English
| MEDLINE | ID: covidwho-1550091
ABSTRACT
Cell adhesion is essential for the formation of organs, cellular migration, and interaction with target cells and the extracellular matrix. Integrins are large protein α/ß-chain heterodimers and form a major family of cell adhesion molecules. Recent research has dramatically increased our knowledge of how integrin phosphorylations regulate integrin activity. Phosphorylations determine the signaling complexes formed on the cytoplasmic tails, regulating downstream signaling. α-Chain phosphorylation is necessary for inducing ß-chain phosphorylation in LFA-1, and the crosstalk from one integrin to another activating or inactivating its function is in part mediated by phosphorylation of ß-chains. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus receptor angiotensin-converting enzyme 2 (ACE2) and possible integrin coreceptors may crosstalk and induce a phosphorylation switch and autophagy.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Integrins
/
COVID-19
Limits:
Humans
Language:
English
Journal:
Trends Biochem Sci
Year:
2022
Document Type:
Article
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