Denaturation of the SARS-CoV-2 spike protein under non-thermal microwave radiation.
Sci Rep
; 11(1): 23373, 2021 12 03.
Article
in English
| MEDLINE | ID: covidwho-1550343
ABSTRACT
SARS-CoV-2, the virus that causes COVID-19, is still a widespread threat to society. The spike protein of this virus facilitates viral entry into the host cell. Here, the denaturation of the S1 subunit of this spike protein by 2.45 GHz electromagnetic radiation was studied quantitatively. The study only pertains to the pure electromagnetic effects by eliminating the bulk heating effect of the microwave radiation in an innovative setup that is capable of controlling the temperature of the sample at any desired intensity of the electromagnetic field. This study was performed at the internal human body temperature, 37 °C, for a relatively short amount of time under a high-power electromagnetic field. The results showed that irradiating the protein with a 700 W, 2.45 GHz electromagnetic field for 2 min can denature the protein to around 95%. In comparison, this is comparable to thermal denaturation at 75 °C for 40 min. Electromagnetic denaturation of the proteins of the virus may open doors to potential therapeutic or sanitation applications.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Protein Denaturation
/
Spike Glycoprotein, Coronavirus
Language:
English
Journal:
Sci Rep
Year:
2021
Document Type:
Article
Affiliation country:
S41598-021-02753-7
Similar
MEDLINE
...
LILACS
LIS