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Virucidal efficacy of guanidine-free inactivants and rapid test buffers against SARS-CoV-2.
Davies, Katherine; Arnold, Ulrike; Buczkowski, Hubert; Burton, Christopher; Welch, Stephen R; Green, Nicole; Strachan, Rhea; Beetar-King, Tracy; Spencer, Peter; Hettiarachchi, Nipunadi; Hannah, Matthew J; Jones, Matthew; Cane, Patricia A; Bruce, Christine B; Woodford, Neil; Roberts, Allen D G; Killip, Marian J.
  • Davies K; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Arnold U; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Buczkowski H; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Burton C; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Welch SR; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Green N; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Strachan R; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Beetar-King T; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Spencer P; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Hettiarachchi N; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Hannah MJ; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Jones M; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Cane PA; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Bruce CB; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Woodford N; NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Roberts ADG; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK.
  • Killip MJ; High Containment Microbiology, NIS Laboratories, National Infection Service, Public Health England, London, NW9 5EQ, UK. marian.killip@phe.gov.uk.
Sci Rep ; 11(1): 23379, 2021 12 03.
Article in English | MEDLINE | ID: covidwho-1550346
ABSTRACT
A pathogen inactivation step during collection or processing of clinical samples has the potential to reduce infectious risks associated with diagnostic procedures. It is essential that these inactivation methods are demonstrated to be effective, particularly for non-traditional inactivation reagents or for commercial products where the chemical composition is undisclosed. This study assessed inactivation effectiveness of twenty-four next-generation (guanidine-free) nucleic acid extraction lysis buffers and twelve rapid antigen test buffers against SARS-CoV-2, the causative agent of COVID-19. These data have significant safety implications for SARS-CoV-2 diagnostic testing and support the design and evidence-based risk assessment of these procedures.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / COVID-19 Serological Testing / SARS-CoV-2 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-02942-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / COVID-19 Serological Testing / SARS-CoV-2 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-02942-4