Non-toxic polymer nanovectors for improved delivery of dexamethasone.
Sci Rep
; 11(1): 17263, 2021 08 26.
Article
in English
| MEDLINE | ID: covidwho-1550348
ABSTRACT
Dexamethasone (Dex) is a highly insoluble front-line drug used in cancer therapy. Data from clinical trials indicates that the pharmacokinetics of Dex vary considerably between patients and prolonging drug exposure rather than increasing absolute dose may improve efficacy. Non-toxic, fully biodegradable Dex loaded nanovectors (NV) were formulated, via simple direct hydration within 10 min, as a vehicle to extend exposure and distribution in vivo. Dex-NV were just as effective as the free drug against primary human leukemia cells in vitro and in vivo. Importantly, high levels of DMSO solvent were not required in the NV formulations. Broad distribution of NV was seen rapidly following inoculation into mice. NV accumulated in major organs, including bone marrow and brain, known sanctuary sites for ALL. The study describes a non-toxic, more easily scalable system for improving Dex solubility for use in cancer and can be applied to other medical conditions associated with inflammation.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Polymers
/
Dexamethasone
/
Drug Delivery Systems
/
Xenograft Model Antitumor Assays
/
Nanostructures
/
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Type of study:
Prognostic study
Limits:
Adult
/
Animals
/
Child
/
Humans
/
Young adult
Language:
English
Journal:
Sci Rep
Year:
2021
Document Type:
Article
Affiliation country:
S41598-021-96797-4
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