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Maternal-Fetal Immunologic Response to SARS-CoV-2 Infection in a Symptomatic Vulnerable Population: A Prospective Cohort.
Larcade, Ramon; DeShea, Lise; Lang, Gillian A; Caballero, Mauricio T; Ferretti, Adrian; Beasley, William H; Tipple, Trent E; Vain, Nestor; Prudent, Luis; Lang, Mark L; Polack, Fernando P; Ofman, Gaston.
  • Larcade R; Fundación para la Salud Materno Infantil, Buenos Aires, Argentina.
  • DeShea L; Department of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
  • Lang GA; Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
  • Caballero MT; Fundación INFANT, Buenos Aires, Argentina.
  • Ferretti A; Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
  • Beasley WH; Fundación INFANT, Buenos Aires, Argentina.
  • Tipple TE; Department of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
  • Vain N; Department of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
  • Prudent L; Fundación para la Salud Materno Infantil, Buenos Aires, Argentina.
  • Lang ML; Fundación para la Salud Materno Infantil, Buenos Aires, Argentina.
  • Polack FP; Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
  • Ofman G; Fundación INFANT, Buenos Aires, Argentina.
J Infect Dis ; 225(5): 800-809, 2022 03 02.
Article in English | MEDLINE | ID: covidwho-1550556
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) disproportionally affects pregnant women and their newborn; however, little is known about variables that modulate maternal-fetal immune response to infection.

METHODS:

We prospectively studied socioeconomic, biologic, and clinical factors affecting humoral immunity in 87 unvaccinated pregnant women hospitalized in Buenos Aires for symptoms consistent with COVID-19.

RESULTS:

The number of days between symptom onset and childbirth predicted maternal and newborn virus spike protein receptor binding domain (RBD)-specific immunoglobulin G (IgG). These findings suggest newborns may benefit less when mothers deliver soon after COVID-19 infection. Similarly, a longer time between symptom onset and birth predicted higher in utero transfer of maternal IgG and its concentration in cord blood. Older gestational age at birth was associated with lower maternal to cord blood IgG ratio. Of women with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, 87% developed RBD-specific IgA responses in breast milk within 96 hours of childbirth. IgA was not significantly associated with time from infection but correlated with maternal serum IgG and placental transfer.

CONCLUSIONS:

These results demonstrate the combined role of biologic, clinical, and socioeconomic variables associated with maternal RBD-specific antibodies and supports early vaccination strategies for COVID-19 in socioeconomically vulnerable pregnant women. CLINICAL TRIALS REGISTRATION NCT04362956.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Adult / Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Adult / Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis