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Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies.
Fagone, Paolo; Ciurleo, Rosella; Lombardo, Salvo Danilo; Iacobello, Carmelo; Palermo, Concetta Ilenia; Shoenfeld, Yehuda; Bendtzen, Klaus; Bramanti, Placido; Nicoletti, Ferdinando.
  • Fagone P; Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
  • Ciurleo R; IRCCS Centro Neurolesi Bonino Pulejo, C.da Casazza, 98124 Messina, Italy. Electronic address: rossella.ciurleo@irccsme.it.
  • Lombardo SD; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, A-1090 Vienna, Austria. Electronic address: SLombardo@cemm.oeaw.ac.at.
  • Iacobello C; UOC Malattie Infettive, AO Cannizzaro, Catania, Italy.
  • Palermo CI; Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
  • Shoenfeld Y; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Aviv University, Israel; I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Sechenov University, Russia. Electronic address: shoenfel@post.tau.ac.il.
  • Bendtzen K; Rigshospitalet University Hospital, Copenhagen, Denmark.
  • Bramanti P; IRCCS Centro Neurolesi Bonino Pulejo, C.da Casazza, 98124 Messina, Italy. Electronic address: placido.bramanti@irccsme.it.
  • Nicoletti F; Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy. Electronic address: ferdinic@unict.it.
Autoimmun Rev ; 19(7): 102571, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-155063
ABSTRACT
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has posed a serious threat to global health. As no specific therapeutics are yet available to control disease evolution, more in-depth understanding of the pathogenic mechanisms induced by SARS-CoV-2 will help to characterize new targets for the management of COVID-19. The present study identified a specific set of biological pathways altered in primary human lung epithelium upon SARS-CoV-2 infection, and a comparison with SARS-CoV from the 2003 pandemic was studied. The transcriptomic profiles were also exploited as possible novel therapeutic targets, and anti-signature perturbation analysis predicted potential drugs to control disease progression. Among them, Mitogen-activated protein kinase kinase (MEK), serine-threonine kinase (AKT), mammalian target of rapamycin (mTOR) and I kappa B Kinase (IKK) inhibitors emerged as candidate drugs. Finally, sex-specific differences that may underlie the higher COVID-19 mortality in men are proposed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Sex Factors / Coronavirus Infections Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Autoimmun Rev Journal subject: Allergy and Immunology Year: 2020 Document Type: Article Affiliation country: J.autrev.2020.102571

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Sex Factors / Coronavirus Infections Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Autoimmun Rev Journal subject: Allergy and Immunology Year: 2020 Document Type: Article Affiliation country: J.autrev.2020.102571