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High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19.
De Zuani, Marco; Laznicková, Petra; Tomasková, Veronika; Dvoncová, Martina; Forte, Giancarlo; Stokin, Gorazd Bernard; Srámek, Vladimir; Helán, Martin; Fric, Jan.
  • De Zuani M; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
  • Laznicková P; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
  • Tomasková V; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
  • Dvoncová M; Department of Anaesthesiology and Intensive Care, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
  • Forte G; Department of Anaesthesiology and Intensive Care, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
  • Stokin GB; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
  • Srámek V; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
  • Helán M; Celica BIOMEDICAL, Ljubljana, Slovenia.
  • Fric J; Department of Anaesthesiology and Intensive Care, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Scand J Immunol ; 95(3): e13125, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1550854
ABSTRACT
Around half of people with severe COVID-19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS-CoV-2 differs between ICU patients that recover and those that do not. We conducted whole-blood immunophenotyping of COVID-19 patients upon admission to ICU and during their treatment and uncovered marked differences in their circulating immune cell subsets. At admission, patients who later succumbed to COVID-19 had significantly lower frequencies of all memory CD8+ T cell subsets, resulting in increased CD4-to-CD8 T cell and neutrophil-to-CD8 T cell ratios. ROC and Kaplan-Meier analyses demonstrated that both CD4-to-CD8 and neutrophil-to-CD8 ratios at admission were strong predictors of in-ICU mortality. Therefore, we propose the use of the CD4-to-CD8 T cell ratio as a marker for the early identification of those individuals likely to require enhanced monitoring and/or pro-active intervention in ICU.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Scand J Immunol Year: 2022 Document Type: Article Affiliation country: Sji.13125

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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Scand J Immunol Year: 2022 Document Type: Article Affiliation country: Sji.13125