TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients

ABSTRACT

Purpose: To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. Methods: TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. Results: There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI 0.243-17.842], even severe [OR = 1.200, 95% CI 0.217-6.638], related to the tt genotype. Conclusion: There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.