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Disorders of Consciousness Associated With COVID-19: A Prospective Multimodal Study of Recovery and Brain Connectivity.
Fischer, David; Snider, Samuel B; Barra, Megan E; Sanders, William R; Rapalino, Otto; Schaefer, Pamela; Foulkes, Andrea S; Bodien, Yelena G; Edlow, Brian L.
  • Fischer D; From the Department of Neurology, (D.F., M.E.B., W.R.S., Y.G.B., B.L.E.), Center for Neurotechnology and Neurorecovery, Department of Pharmacy (M.E.B.), Department of Radiology (O.R., P.S.), and Department of Medicine (A.S.F.), Massachusetts General Hospital and Harvard Medical School; Division of N
  • Snider SB; From the Department of Neurology, (D.F., M.E.B., W.R.S., Y.G.B., B.L.E.), Center for Neurotechnology and Neurorecovery, Department of Pharmacy (M.E.B.), Department of Radiology (O.R., P.S.), and Department of Medicine (A.S.F.), Massachusetts General Hospital and Harvard Medical School; Division of N
  • Barra ME; From the Department of Neurology, (D.F., M.E.B., W.R.S., Y.G.B., B.L.E.), Center for Neurotechnology and Neurorecovery, Department of Pharmacy (M.E.B.), Department of Radiology (O.R., P.S.), and Department of Medicine (A.S.F.), Massachusetts General Hospital and Harvard Medical School; Division of N
  • Sanders WR; From the Department of Neurology, (D.F., M.E.B., W.R.S., Y.G.B., B.L.E.), Center for Neurotechnology and Neurorecovery, Department of Pharmacy (M.E.B.), Department of Radiology (O.R., P.S.), and Department of Medicine (A.S.F.), Massachusetts General Hospital and Harvard Medical School; Division of N
  • Rapalino O; From the Department of Neurology, (D.F., M.E.B., W.R.S., Y.G.B., B.L.E.), Center for Neurotechnology and Neurorecovery, Department of Pharmacy (M.E.B.), Department of Radiology (O.R., P.S.), and Department of Medicine (A.S.F.), Massachusetts General Hospital and Harvard Medical School; Division of N
  • Schaefer P; From the Department of Neurology, (D.F., M.E.B., W.R.S., Y.G.B., B.L.E.), Center for Neurotechnology and Neurorecovery, Department of Pharmacy (M.E.B.), Department of Radiology (O.R., P.S.), and Department of Medicine (A.S.F.), Massachusetts General Hospital and Harvard Medical School; Division of N
  • Foulkes AS; From the Department of Neurology, (D.F., M.E.B., W.R.S., Y.G.B., B.L.E.), Center for Neurotechnology and Neurorecovery, Department of Pharmacy (M.E.B.), Department of Radiology (O.R., P.S.), and Department of Medicine (A.S.F.), Massachusetts General Hospital and Harvard Medical School; Division of N
  • Bodien YG; From the Department of Neurology, (D.F., M.E.B., W.R.S., Y.G.B., B.L.E.), Center for Neurotechnology and Neurorecovery, Department of Pharmacy (M.E.B.), Department of Radiology (O.R., P.S.), and Department of Medicine (A.S.F.), Massachusetts General Hospital and Harvard Medical School; Division of N
  • Edlow BL; From the Department of Neurology, (D.F., M.E.B., W.R.S., Y.G.B., B.L.E.), Center for Neurotechnology and Neurorecovery, Department of Pharmacy (M.E.B.), Department of Radiology (O.R., P.S.), and Department of Medicine (A.S.F.), Massachusetts General Hospital and Harvard Medical School; Division of N
Neurology ; 98(3): e315-e325, 2022 01 18.
Article in English | MEDLINE | ID: covidwho-1551285
ABSTRACT
BACKGROUND AND

OBJECTIVES:

In patients with severe coronavirus disease 2019 (COVID-19), disorders of consciousness (DoC) have emerged as a serious complication. The prognosis and pathophysiology of COVID-DoC remain unclear, complicating decisions about continuing life-sustaining treatment. We describe the natural history of COVID-DoC and investigate its associated brain connectivity profile.

METHODS:

In a prospective longitudinal study, we screened consecutive patients with COVID-19 at our institution. We enrolled critically ill adult patients with a DoC unexplained by sedation or structural brain injury and who were planned to undergo a brain MRI. We performed resting-state fMRI and diffusion MRI to evaluate functional and structural connectivity compared to healthy controls and patients with DoC resulting from severe traumatic brain injury (TBI). We assessed the recovery of consciousness (command following) and functional outcomes (Glasgow Outcome Scale Extended [GOSE] and the Disability Rating Scale [DRS]) at hospital discharge and 3 and 6 months after discharge. We also explored whether clinical variables were associated with recovery from COVID-DoC.

RESULTS:

After screening 1,105 patients with COVID-19, we enrolled 12 with COVID-DoC. The median age was 63.5 years (interquartile range 55-76.3 years). After the exclusion of 1 patient who died shortly after enrollment, all of the remaining 11 patients recovered consciousness 0 to 25 days (median 7 [5-14.5] days) after the cessation of continuous IV sedation. At discharge, all surviving patients remained dependent median GOSE score 3 (1-3) and median DRS score 23 (16-30). Ultimately, however, except for 2 patients with severe polyneuropathy, all returned home with normal cognition and minimal disability at 3 months, median GOSE score 3 (3-3) and median DRS score 7 (5-13); at 6 months, median GOSE score 4 (4-5), median DRS score 3 (3-5). Ten patients with COVID-DoC underwent advanced neuroimaging; functional and structural brain connectivity in those with COVID-DoC was diminished compared to healthy controls, and structural connectivity was comparable to that in patients with severe TBI.

DISCUSSION:

Patients who survived invariably recovered consciousness after COVID-DoC. Although disability was common after hospitalization, functional status improved over the ensuing months. While future research is necessary, these prospective findings inform the prognosis and pathophysiology of COVID-DoC. TRIAL REGISTRATION INFORMATION ClinicalTrials.gov identifier NCT04476589.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Consciousness Disorders / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Aged / Humans / Middle aged Language: English Journal: Neurology Year: 2022 Document Type: Article Affiliation country: Wnl.0000000000013067

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Consciousness Disorders / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Aged / Humans / Middle aged Language: English Journal: Neurology Year: 2022 Document Type: Article Affiliation country: Wnl.0000000000013067