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A brief review on DNA vaccines in the era of COVID-19.
Shafaati, Maryam; Saidijam, Massoud; Soleimani, Meysam; Hazrati, Fereshte; Mirzaei, Rasoul; Amirheidari, Bagher; Tanzadehpanah, Hamid; Karampoor, Sajad; Kazemi, Sima; Yavari, Bahram; Mahaki, Hanie; Safaei, Mohsen; Rahbarizadeh, Fatemeh; Samadi, Pouria; Ahmadyousefi, Yaghoub.
  • Shafaati M; Department of Microbiology, Faculty of Sciences, Jahrom Branch, Islamic Azad University, Jahrom, Iran.
  • Saidijam M; Department of Medical Biotechnology, School of Advanced Medical Sciences & Technologies, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Soleimani M; Research Center for Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Hazrati F; Department of Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Mirzaei R; Department of Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Amirheidari B; Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Tanzadehpanah H; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
  • Karampoor S; Extremophile and Productive Microorganisms Research Center, Kerman University of Medical Sciences, Kerman, Iran.
  • Kazemi S; Department of Medical Biotechnology, School of Advanced Medical Sciences & Technologies, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Yavari B; Research Center for Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Mahaki H; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Safaei M; Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Rahbarizadeh F; Department of Medical Biotechnology, School of Advanced Medical Sciences & Technologies, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Samadi P; Research Center for Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Ahmadyousefi Y; Vascular & Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Future Virol ; 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1551416
ABSTRACT
This article provides a brief overview of DNA vaccines. First, the basic DNA vaccine design strategies are described, then specific issues related to the industrial production of DNA vaccines are discussed, including the production and purification of DNA products such as plasmid DNA, minicircle DNA, minimalistic, immunologically defined gene expression (MIDGE) and Doggybone™. The use of adjuvants to enhance the immunogenicity of DNA vaccines is then discussed. In addition, different delivery routes and several physical and chemical methods to increase the efficacy of DNA delivery into cells are explained. Recent preclinical and clinical trials of DNA vaccines for COVID-19 are then summarized. Lastly, the advantages and obstacles of DNA vaccines are discussed.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Fvl-2021-0170

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Fvl-2021-0170