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The CREST-2 experience with the evolving challenges of COVID-19: A clinical trial in a pandemic.
Meschia, James F; Barrett, Kevin M; Brown, Robert D; Turan, Tanya N; Howard, Virginia J; Voeks, Jenifer H; Lal, Brajesh K; Howard, George; Brott, Thomas G.
  • Meschia JF; From the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Bi
  • Barrett KM; From the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Bi
  • Brown RD; From the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Bi
  • Turan TN; From the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Bi
  • Howard VJ; From the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Bi
  • Voeks JH; From the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Bi
  • Lal BK; From the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Bi
  • Howard G; From the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Bi
  • Brott TG; From the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Bi
Neurology ; 95(1): 29-36, 2020 07 07.
Article in English | MEDLINE | ID: covidwho-155213
ABSTRACT
The coronavirus disease 2019 pandemic has disrupted the lives of whole communities and nations. The multinational multicenter National Institute of Neurological Disorders and Stroke Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial stroke prevention trial rapidly experienced the effects of the pandemic and had to temporarily suspend new enrollments and shift patient follow-up activities from in-person clinic visits to telephone contacts. There is an ethical obligation to the patients to protect their health while taking every feasible step to ensure that the goals of the trial are successfully met. Here, we describe the effects of the pandemic on the trial and steps that are being taken to mitigate the effects of the pandemic so that trial objectives can be met.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Randomized Controlled Trials as Topic / Carotid Stenosis / Coronavirus Infections / Stroke / Pandemics Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America / Europa Language: English Journal: Neurology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Randomized Controlled Trials as Topic / Carotid Stenosis / Coronavirus Infections / Stroke / Pandemics Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America / Europa Language: English Journal: Neurology Year: 2020 Document Type: Article