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Accessory protein: a type of protein that cannot be ignored by coronavirus
Weishengwuxue Tongbao = Microbiology ; - (10):3895, 2021.
Article in English | ProQuest Central | ID: covidwho-1553107
ABSTRACT
Coronaviruses (CoVs) are the largest single-stranded positive-stranded RNA viruses in the genome. Most of them can spread across species and infect humans. They are currently one of the pathogens that cause major public health incidents and seriously threaten human health. The viral genome is about 25-31 kb in length, encoding multiple non-structural proteins, structural proteins (S, E, M, N) and accessory proteins. For most coronaviruses, although accessory protein is a non-essential protein for virus replication, it often plays an important role in the pathogenic process of the virus and is an important functional protein for coronaviruses. This type of protein is located at the 3′ end of the viral genome, and the transcription of the mRNA is regulated by the transcription regulating sequence (TRS) located at the start position of the gene, and the codon usage preference of the protein coding sequence also produces protein translation. Significant influence. The accessory protein has the properties of a transmembrane protein and a unique protein transport motif. The latter plays a decisive role in the formation of the transmembrane region, the topological structure of the protein, and the intracellular transport process of the protein, which directly affects the function of the accessory protein. . This article first summarizes the latest classification and genome structure of coronaviruses;then systematically summarizes relevant research progress in terms of the types, functions, protein transport motifs, topological structures, and codon usage preferences of accessory proteins, and then provides an overview of the next step The research direction has been prospected, which provides an important reference for a more comprehensive understanding of the biological characteristics of the coronavirus accessory protein.
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Collection: Databases of international organizations Database: ProQuest Central Language: English Journal: Weishengwuxue Tongbao = Microbiology Year: 2021 Document Type: Article

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Collection: Databases of international organizations Database: ProQuest Central Language: English Journal: Weishengwuxue Tongbao = Microbiology Year: 2021 Document Type: Article