Pulmonary Embolism and Increased Levels of d-Dimer in Patients with Coronavirus Disease.

Griffin, Daniel O; Jensen, Alexandra; Khan, Mushmoom; Chin, Jessica; Chin, Kelly; Saad, Jennifer; Parnell, Ryan; Awwad, Christopher; Patel, Darshan

Griffin, Daniel O; Jensen, Alexandra; Khan, Mushmoom; Chin, Jessica; Chin, Kelly; Saad, Jennifer; Parnell, Ryan; Awwad, Christopher; Patel, Darshan.

Emerg Infect Dis ; 26(8): 1941-1943, 2020 Aug.

Article in English | MEDLINE | ID: covidwho-155428

ABSTRACT

ABSTRACT

We report 3 patients with coronavirus disease who had a decline in respiratory status during their hospital course that responded well to intravenous steroids and interleukin-6 receptor antagonist therapy. These patients later showed development of persistent hypoxia with increased levels of d-dimer levels and were given a diagnosis of pulmonary embolisms.

Subject(s)

Betacoronavirus/pathogenicity; Coronavirus Infections/complications; Cytokine Release Syndrome/complications; Fibrin Fibrinogen Degradation Products/metabolism; Hypoxia/complications; Pneumonia, Viral/complications; Pulmonary Embolism/complications; Acute Disease; Aged; Antibodies, Monoclonal, Humanized/therapeutic use; Anticoagulants/therapeutic use; Betacoronavirus/drug effects; Betacoronavirus/physiology; Biomarkers/blood; COVID-19; COVID-19 Testing; Clinical Laboratory Techniques/methods; Coronavirus Infections/diagnosis; Coronavirus Infections/drug therapy; Coronavirus Infections/virology; Cytokine Release Syndrome/diagnosis; Cytokine Release Syndrome/drug therapy; Cytokine Release Syndrome/virology; Enoxaparin/therapeutic use; Female; Humans; Hypoxia/diagnosis; Hypoxia/drug therapy; Hypoxia/virology; Male; Methylprednisolone Hemisuccinate/therapeutic use; Middle Aged; Pandemics; Pneumonia, Viral/diagnosis; Pneumonia, Viral/drug therapy; Pneumonia, Viral/virology; Pulmonary Embolism/diagnosis; Pulmonary Embolism/drug therapy; Pulmonary Embolism/virology; Rivaroxaban/therapeutic use; SARS-CoV-2; Tomography, X-Ray Computed; Treatment Outcome

Keywords

COVID-19; SARS-CoV-2; coronavirus disease; d-dimer; deep vein thrombosis; hypercoagulability; prophylaxis; pulmonary embolism; respiratory infections; sequelae; severe acute respiratory syndrome coronavirus 2; thromboembolic; viruses

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pulmonary Embolism / Fibrin Fibrinogen Degradation Products / Coronavirus Infections / Betacoronavirus / Cytokine Release Syndrome / Hypoxia Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid Language: English Journal: Emerg Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article

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