Your browser doesn't support javascript.
Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions.
Tan, Ping-Heng; Ji, Jasmine; Yeh, Chun-Chang; Ji, Ru-Rong.
  • Tan PH; Department of Anesthesiology, Chi Mei Medical Center, Tainan City, Taiwan.
  • Ji J; Neuroscience Department, Wellesley College, Wellesley, Massachusetts, MA, United States.
  • Yeh CC; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, United States.
  • Ji RR; Department of Anesthesiology of Tri-Service General Hospital & National Defense Medical Center, Taipei City, Taiwan.
Front Immunol ; 12: 783725, 2021.
Article in English | MEDLINE | ID: covidwho-1554650
ABSTRACT
Interferons (IFNs) are cytokines that possess antiviral, antiproliferative, and immunomodulatory actions. IFN-α and IFN-ß are two major family members of type-I IFNs and are used to treat diseases, including hepatitis and multiple sclerosis. Emerging evidence suggests that type-I IFN receptors (IFNARs) are also expressed by microglia, astrocytes, and neurons in the central and peripheral nervous systems. Apart from canonical transcriptional regulations, IFN-α and IFN-ß can rapidly suppress neuronal activity and synaptic transmission via non-genomic regulation, leading to potent analgesia. IFN-γ is the only member of the type-II IFN family and induces central sensitization and microglia activation in persistent pain. We discuss how type-I and type-II IFNs regulate pain and infection via neuro-immune modulations, with special focus on neuroinflammation and neuro-glial interactions. We also highlight distinct roles of type-I IFNs in the peripheral and central nervous system. Insights into IFN signaling in nociceptors and their distinct actions in physiological vs. pathological and acute vs. chronic conditions will improve our treatments of pain after surgeries, traumas, and infections.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / Interferon-gamma / Acute Pain / Chronic Pain / Neuroinflammatory Diseases Limits: Animals / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.783725

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / Interferon-gamma / Acute Pain / Chronic Pain / Neuroinflammatory Diseases Limits: Animals / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.783725