Your browser doesn't support javascript.
Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection.
Bauer, Wolfgang; Weber, Marcus; Diehl-Wiesenecker, Eva; Galtung, Noa; Prpic, Monika; Somasundaram, Rajan; Tauber, Rudolf; Schwenk, Jochen M; Micke, Patrick; Kappert, Kai.
  • Bauer W; Department of Emergency Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203 Berlin, Germany.
  • Weber M; Zuse Institute Berlin (ZIB), Takustraße 7, 14195 Berlin, Germany.
  • Diehl-Wiesenecker E; Department of Emergency Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203 Berlin, Germany.
  • Galtung N; Department of Emergency Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203 Berlin, Germany.
  • Prpic M; Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
  • Somasundaram R; Department of Emergency Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203 Berlin, Germany.
  • Tauber R; Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
  • Schwenk JM; Labor Berlin-Charité Vivantes GmbH, 13353 Berlin, Germany.
  • Micke P; Science for Life Laboratory, KTH-Royal Institute of Technology, Tomtebodavägen 23, 17165 Solna, Sweden.
  • Kappert K; Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjölds Väg 20, 75185 Uppsala, Sweden.
Viruses ; 13(12)2021 12 07.
Article in English | MEDLINE | ID: covidwho-1554805
ABSTRACT

BACKGROUND:

We evaluated how plasma proteomic signatures in patients with suspected COVID-19 can unravel the pathophysiology, and determine kinetics and clinical outcome of the infection.

METHODS:

Plasma samples from patients presenting to the emergency department (ED) with symptoms of COVID-19 were stratified into (1) patients with suspected COVID-19 that was not confirmed (n = 44); (2) non-hospitalized patients with confirmed COVID-19 (n = 44); (3) hospitalized patients with confirmed COVID-19 (n = 53) with variable outcome; and (4) patients presenting to the ED with minor diseases unrelated to SARS-CoV-2 infection (n = 20). Besides standard of care diagnostics, 177 circulating proteins related to inflammation and cardiovascular disease were analyzed using proximity extension assay (PEA, Olink) technology.

RESULTS:

Comparative proteome analysis revealed 14 distinct proteins as highly associated with SARS-CoV-2 infection and 12 proteins with subsequent hospitalization (p < 0.001). ADM, IL-6, MCP-3, TRAIL-R2, and PD-L1 were each predictive for death (AUROC curve 0.80-0.87). The consistent increase of these markers, from hospital admission to intensive care and fatality, supported the concept that these proteins are of major clinical relevance.

CONCLUSIONS:

We identified distinct plasma proteins linked to the presence and course of COVID-19. These plasma proteomic findings may translate to a protein fingerprint, helping to assist clinical management decisions.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Plasma / Biomarkers / Proteome / COVID-19 Type of study: Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: V13122456

Full text: Available Collection: International databases Database: MEDLINE Main subject: Plasma / Biomarkers / Proteome / COVID-19 Type of study: Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: V13122456