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A Rapid Systematic Review of Clinical Trials Utilizing Chloroquine and Hydroxychloroquine as a Treatment for COVID-19.
Chowdhury, Md Sadakat; Rathod, Jay; Gernsheimer, Joel.
  • Chowdhury MS; From the, SUNY Downstate Medical Center, Brooklyn, NY.
  • Rathod J; From the, SUNY Downstate Medical Center, Brooklyn, NY.
  • Gernsheimer J; Department of Emergency Medicine, SUNY Downstate Medical Center, Brooklyn, NY.
Acad Emerg Med ; 27(6): 493-504, 2020 06.
Article in English | MEDLINE | ID: covidwho-155481
Semantic information from SemMedBD (by NLM)
1. chloroquine TREATS COVID-19
Subject
chloroquine
Predicate
TREATS
Object
COVID-19
2. hydroxychloroquine TREATS COVID-19
Subject
hydroxychloroquine
Predicate
TREATS
Object
COVID-19
3. chloroquine ADMINISTERED_TO Patients
Subject
chloroquine
Predicate
ADMINISTERED_TO
Object
Patients
4. hydroxychloroquine ADMINISTERED_TO Patients
Subject
hydroxychloroquine
Predicate
ADMINISTERED_TO
Object
Patients
5. chloroquine TREATS COVID-19
Subject
chloroquine
Predicate
TREATS
Object
COVID-19
6. hydroxychloroquine TREATS COVID-19
Subject
hydroxychloroquine
Predicate
TREATS
Object
COVID-19
7. chloroquine ADMINISTERED_TO Patients
Subject
chloroquine
Predicate
ADMINISTERED_TO
Object
Patients
8. hydroxychloroquine ADMINISTERED_TO Patients
Subject
hydroxychloroquine
Predicate
ADMINISTERED_TO
Object
Patients
ABSTRACT

OBJECTIVES:

The emergence of SARS-CoV-2 has presented clinicians with a difficult therapeutic dilemma. With supportive care as the current mainstay of treatment, the fatality rate of COVID-19 is 6.9%. There are currently several trials assessing the efficacy of different antivirals as treatment. Of these, chloroquine (CQ) and its derivative hydroxychloroquine (HCQ) have garnered the most attention.

METHODS:

In this study, the literature currently available on CQ and HCQ as treatment of COVID-19 was surveyed using EMBASE, PubMed, Cochrane Library, MedRxiv, and one clinical trial registry. Upon gathering published and preprint trials, risk of bias was assessed using Cochrane Risk of Bias Tool 2.0.

RESULTS:

There are currently seven completed clinical trials and 29 registered clinical trials focusing on HCQ or CQ as a therapeutic avenue for COVID-19. Of these, five of seven trials have shown favorable outcomes for patients using CQ or HCQ and two of seven have shown no change compared to control. However, all seven trials carried varying degrees of bias and poor study design.

CONCLUSION:

There are currently not enough data available to support the routine use of HCQ and CQ as therapies for COVID-19. Pending further results from more extensive studies with more stringent study parameters, clinicians should defer from routine use of HCQ and CQ. There are several clinical trials currently under way with results expected soon.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pneumonia, Viral / Chloroquine / Coronavirus Infections / Hydroxychloroquine / Antimalarials Subject: Pneumonia, Viral / Chloroquine / Coronavirus Infections / Hydroxychloroquine / Antimalarials Type of study: Controlled clinical trial / Clinical Practice Guide / Systematic review Language: English Journal: Acad Emerg Med Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pneumonia, Viral / Chloroquine / Coronavirus Infections / Hydroxychloroquine / Antimalarials Subject: Pneumonia, Viral / Chloroquine / Coronavirus Infections / Hydroxychloroquine / Antimalarials Type of study: Controlled clinical trial / Clinical Practice Guide / Systematic review Language: English Journal: Acad Emerg Med Year: 2020
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