The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2.
Medicina (Kaunas)
; 57(12)2021 Dec 02.
Article
in English
| MEDLINE | ID: covidwho-1554816
ABSTRACT
Vaccines are the only way to reduce the morbidity associated to SARS-CoV-2 infection. The appearance of new mutations urges us to increase the effectiveness of vaccines as a complementary alternative. In this context, the use of adjuvant strategies has improved the effectiveness of different vaccines against virus infections such as dengue, influenza, and common cold. Recent reports on patients infected by COVID-19 reveal that low levels of circulating vitamin D correlate with a severe respiratory insufficiency. The immunomodulatory activity of this micronutrient attenuates the synthesis of pro-inflammatory cytokines and at the same time, increases antibody production. Therefore, the present review proposes the use of vitamin D as adjuvant micronutrient to increase the efficacy of vaccines against SARS-CoV-2 infection.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal subject:
Medicine
Year:
2021
Document Type:
Article
Affiliation country:
Medicina57121321
Similar
MEDLINE
...
LILACS
LIS