LPS versus Poly I:C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring.
Am J Physiol Regul Integr Comp Physiol
; 322(2): R99-R111, 2022 02 01.
Article
in English
| MEDLINE | ID: covidwho-2162033
ABSTRACT
A prominent health issue nowadays is the COVID-19 pandemic, which poses acute risks to human health. However, the long-term health consequences are largely unknown and cannot be neglected. An especially vulnerable period for infection is pregnancy, when infections could have long-term health effect on the child. Evidence suggests that maternal immune activation (MIA) induced by either bacteria or viruses presents various effects on the offspring, leading to adverse phenotypes in many organ systems. This review compares the mechanisms of bacterial and viral MIA and the possible long-term outcomes for the offspring by summarizing the outcome in animal LPS and Poly IC models. Both models are activated immune responses mediated by Toll-like receptors. The outcomes for MIA offspring include neurodevelopment, immune response, circulation, metabolism, and reproduction. Some of these changes continue to exist until later life. Besides different doses and batches of LPS and Poly IC, the injection day, administration route, and also different animal species influence the outcomes. Here, we specifically aim to support colleagues when choosing their animal models for future studies.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Prenatal Exposure Delayed Effects
/
Lipopolysaccharides
/
Poly I-C
/
SARS-CoV-2
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
Topics:
Long Covid
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Am J Physiol Regul Integr Comp Physiol
Journal subject:
Physiology
Year:
2022
Document Type:
Article
Affiliation country:
AJPREGU.00087.2021
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