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Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine.
Cait, Alissa; Mooney, Anna; Poyntz, Hazel; Shortt, Nick; Jones, Angela; Gestin, Aurélie; Gell, Katie; Grooby, Alix; O'Sullivan, David; Tang, Jeffry S; Young, Wayne; Thayabaran, Darmiga; Sparks, Jenny; Ostapowicz, Tess; Tay, Audrey; Poppitt, Sally D; Elliott, Sarah; Wakefield, Georgia; Parry-Strong, Amber; Ralston, Jacqui; Beasley, Richard; Weatherall, Mark; Braithwaite, Irene; Forbes-Blom, Elizabeth; Gasser, Olivier.
  • Cait A; Malaghan Institute of Medical Research, Wellington, New Zealand.
  • Mooney A; Malaghan Institute of Medical Research, Wellington, New Zealand.
  • Poyntz H; High-Value Nutrition National Science Challenge, Auckland, New Zealand.
  • Shortt N; Malaghan Institute of Medical Research, Wellington, New Zealand.
  • Jones A; High-Value Nutrition National Science Challenge, Auckland, New Zealand.
  • Gestin A; High-Value Nutrition National Science Challenge, Auckland, New Zealand.
  • Gell K; Medical Research Institute of New Zealand, Wellington, New Zealand.
  • Grooby A; Malaghan Institute of Medical Research, Wellington, New Zealand.
  • O'Sullivan D; High-Value Nutrition National Science Challenge, Auckland, New Zealand.
  • Tang JS; Malaghan Institute of Medical Research, Wellington, New Zealand.
  • Young W; High-Value Nutrition National Science Challenge, Auckland, New Zealand.
  • Thayabaran D; Malaghan Institute of Medical Research, Wellington, New Zealand.
  • Sparks J; Malaghan Institute of Medical Research, Wellington, New Zealand.
  • Ostapowicz T; Malaghan Institute of Medical Research, Wellington, New Zealand.
  • Tay A; High-Value Nutrition National Science Challenge, Auckland, New Zealand.
  • Poppitt SD; Malaghan Institute of Medical Research, Wellington, New Zealand.
  • Elliott S; High-Value Nutrition National Science Challenge, Auckland, New Zealand.
  • Wakefield G; High-Value Nutrition National Science Challenge, Auckland, New Zealand.
  • Parry-Strong A; AgResearch, Palmerston North, New Zealand.
  • Ralston J; High-Value Nutrition National Science Challenge, Auckland, New Zealand.
  • Beasley R; Medical Research Institute of New Zealand, Wellington, New Zealand.
  • Weatherall M; High-Value Nutrition National Science Challenge, Auckland, New Zealand.
  • Braithwaite I; Medical Research Institute of New Zealand, Wellington, New Zealand.
  • Forbes-Blom E; High-Value Nutrition National Science Challenge, Auckland, New Zealand.
  • Gasser O; Medical Research Institute of New Zealand, Wellington, New Zealand.
Front Immunol ; 12: 765528, 2021.
Article in English | MEDLINE | ID: covidwho-1555219
ABSTRACT
Influenza vaccination is an effective public health measure to reduce the risk of influenza illness, particularly when the vaccine is well matched to circulating strains. Notwithstanding, the efficacy of influenza vaccination varies greatly among vaccinees due to largely unknown immunological determinants, thereby dampening population-wide protection. Here, we report that dietary fibre may play a significant role in humoral vaccine responses. We found dietary fibre intake and the abundance of fibre-fermenting intestinal bacteria to be positively correlated with humoral influenza vaccine-specific immune responses in human vaccinees, albeit without reaching statistical significance. Importantly, this correlation was largely driven by first-time vaccinees; prior influenza vaccination negatively correlated with vaccine immunogenicity. In support of these observations, dietary fibre consumption significantly enhanced humoral influenza vaccine responses in mice, where the effect was mechanistically linked to short-chain fatty acids, the bacterial fermentation product of dietary fibre. Overall, these findings may bear significant importance for emerging infectious agents, such as COVID-19, and associated de novo vaccinations.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dietary Fiber / Influenza Vaccines / Influenza, Human / Immunity, Humoral Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.765528

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dietary Fiber / Influenza Vaccines / Influenza, Human / Immunity, Humoral Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.765528