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Single cell atlas for 11 non-model mammals, reptiles and birds.
Chen, Dongsheng; Sun, Jian; Zhu, Jiacheng; Ding, Xiangning; Lan, Tianming; Wang, Xiran; Wu, Weiying; Ou, Zhihua; Zhu, Linnan; Ding, Peiwen; Wang, Haoyu; Luo, Lihua; Xiang, Rong; Wang, Xiaoling; Qiu, Jiaying; Wang, Shiyou; Li, Haimeng; Chai, Chaochao; Liang, Langchao; An, Fuyu; Zhang, Le; Han, Lei; Zhu, Yixin; Wang, Feiyue; Yuan, Yuting; Wu, Wendi; Sun, Chengcheng; Lu, Haorong; Wu, Jihong; Sun, Xinghuai; Zhang, Shenghai; Sahu, Sunil Kumar; Liu, Ping; Xia, Jun; Zhang, Lijing; Chen, Haixia; Fang, Dongming; Zeng, Yuying; Wu, Yiquan; Cui, Zehua; He, Qian; Jiang, Sanjie; Ma, Xiaoyan; Feng, Weimin; Xu, Yan; Li, Fang; Liu, Zhongmin; Chen, Lei; Chen, Fang; Jin, Xin.
  • Chen D; BGI-Shenzhen, Shenzhen, 518083, China.
  • Sun J; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, 510642, China.
  • Zhu J; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
  • Ding X; BGI-Shenzhen, Shenzhen, 518083, China.
  • Lan T; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Wang X; BGI-Shenzhen, Shenzhen, 518083, China.
  • Wu W; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Ou Z; BGI-Shenzhen, Shenzhen, 518083, China.
  • Zhu L; Department of Biology, University of Copenhagen, DK-2100, Copenhagen, Denmark.
  • Ding P; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, 510642, China.
  • Wang H; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
  • Luo L; BGI-Shenzhen, Shenzhen, 518083, China.
  • Xiang R; BGI-Shenzhen, Shenzhen, 518083, China.
  • Wang X; BGI-Shenzhen, Shenzhen, 518083, China.
  • Qiu J; BGI-Shenzhen, Shenzhen, 518083, China.
  • Wang S; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Li H; BGI-Shenzhen, Shenzhen, 518083, China.
  • Chai C; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Liang L; BGI-Shenzhen, Shenzhen, 518083, China.
  • An F; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Zhang L; BGI-Shenzhen, Shenzhen, 518083, China.
  • Han L; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Zhu Y; BGI-Shenzhen, Shenzhen, 518083, China.
  • Wang F; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Yuan Y; BGI-Shenzhen, Shenzhen, 518083, China.
  • Wu W; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Sun C; BGI-Shenzhen, Shenzhen, 518083, China.
  • Lu H; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Wu J; BGI-Shenzhen, Shenzhen, 518083, China.
  • Sun X; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Zhang S; BGI-Shenzhen, Shenzhen, 518083, China.
  • Sahu SK; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Liu P; BGI-Shenzhen, Shenzhen, 518083, China.
  • Xia J; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Zhang L; Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, Guangdong Academy of Forestry, Guangzhou, 510520, China.
  • Chen H; College of Wildlife Resources Northeast Forestry University, Harbin, 150040, China.
  • Fang D; College of Wildlife Resources Northeast Forestry University, Harbin, 150040, China.
  • Zeng Y; BGI-Shenzhen, Shenzhen, 518083, China.
  • Wu Y; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Cui Z; BGI-Shenzhen, Shenzhen, 518083, China.
  • He Q; BGI-Shenzhen, Shenzhen, 518083, China.
  • Jiang S; BGI-Shenzhen, Shenzhen, 518083, China.
  • Ma X; BGI-Shenzhen, Shenzhen, 518083, China.
  • Feng W; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Xu Y; China National Genebank, BGI-Shenzhen, Shenzhen, 518120, China.
  • Li F; Shenzhen Key Laboratory of Environmental Microbial Genomics and Application, BGI-Shenzhen, Shenzhen, 518120, China.
  • Liu Z; Eye and ENT Hospital, College of Medicine, Fudan University, Shanghai, China.
  • Chen L; Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Shanghai, China.
  • Chen F; Key Laboratory of Myopia, Ministry of Health, Shanghai, China.
  • Jin X; Eye and ENT Hospital, College of Medicine, Fudan University, Shanghai, China.
Nat Commun ; 12(1): 7083, 2021 12 06.
Article in English | MEDLINE | ID: covidwho-1555251
ABSTRACT
The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening of animal cells could reveal the expression patterns of viral entry genes in different hosts. However, such exploration for SARS-CoV-2 remains limited. Here, we perform single-nucleus RNA sequencing for 11 non-model species, including pets (cat, dog, hamster, and lizard), livestock (goat and rabbit), poultry (duck and pigeon), and wildlife (pangolin, tiger, and deer), and investigated the co-expression of ACE2 and TMPRSS2. Furthermore, cross-species analysis of the lung cell atlas of the studied mammals, reptiles, and birds reveals core developmental programs, critical connectomes, and conserved regulatory circuits among these evolutionarily distant species. Overall, our work provides a compendium of gene expression profiles for non-model animals, which could be employed to identify potential SARS-CoV-2 target cells and putative zoonotic reservoirs.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Atlases as Topic / Single-Cell Analysis Type of study: Randomized controlled trials Limits: Animals Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-27162-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Atlases as Topic / Single-Cell Analysis Type of study: Randomized controlled trials Limits: Animals Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-27162-2