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Immunologic memory to SARS-CoV-2 in convalescent COVID-19 patients at 1 year postinfection.
Hou, Hongyan; Zhang, Yandi; Tang, Guoxing; Luo, Ying; Liu, Wei; Cheng, Chang; Jiang, Yuhuan; Xiong, Zhigang; Wu, Shiji; Sun, Ziyong; Xu, Shabei; Fan, Xionglin; Wang, Feng.
  • Hou H; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang Y; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Tang G; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Luo Y; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Liu W; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Cheng C; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Jiang Y; Department of Clinical Laboratory, First Affiliated Hospital of Nanchang University, Nanchang, China.
  • Xiong Z; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wu S; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: wilson547@163.com.
  • Sun Z; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: zysun@tjh.tjmu.edu.cn.
  • Xu S; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: xushabei@126.com.
  • Fan X; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: xlfan@hust.edu.cn.
  • Wang F; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: fengwang@tjh.tjmu.edu.cn.
J Allergy Clin Immunol ; 148(6): 1481-1492.e2, 2021 12.
Article in English | MEDLINE | ID: covidwho-1555521
ABSTRACT

BACKGROUND:

Understanding the complexities of immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is key to gain insights into the durability of protective immunity against reinfection.

OBJECTIVE:

We sought to evaluate the immune memory to SARS-CoV-2 in convalescent patients with longer follow-up time.

METHODS:

SARS-CoV-2-specific humoral and cellular responses were assessed in convalescent patients with coronavirus disease 2019 (COVID-19) at 1 year postinfection.

RESULTS:

A total of 78 convalescent patients with COVID-19 (26 moderate, 43 severe, and 9 critical) were recruited after 1 year of recovery. The positive rates of both anti-receptor-binding domain and antinucleocapsid antibodies were 100%, whereas we did not observe a statistical difference in antibody levels among different severity groups. Accordingly, the prevalence of neutralizing antibodies (nAbs) reached 93.59% in convalescent patients. Although nAb titers displayed an increasing trend in convalescent patients with increased severity, the difference failed to achieve statistical significance. Notably, there was a significant correlation between nAb titers and anti-receptor-binding domain levels. Interestingly, SARS-CoV-2-specific T cells could be robustly maintained in convalescent patients, and their number was positively correlated with both nAb titers and anti-receptor-binding domain levels. Amplified SARS-CoV-2-specific CD4+ T cells mainly produced a single cytokine, accompanying with increased expression of exhaustion markers including PD-1, Tim-3, TIGIT, CTLA-4, and CD39, while the proportion of multifunctional cells was low.

CONCLUSIONS:

Robust SARS-CoV-2-specific humoral and cellular responses are maintained in convalescent patients with COVID-19 at 1 year postinfection. However, the dysfunction of SARS-CoV-2-specific CD4+ T cells supports the notion that vaccination is needed in convalescent patients for preventing reinfection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / COVID-19 / Immunologic Memory Type of study: Randomized controlled trials / Risk factors Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: J Allergy Clin Immunol Year: 2021 Document Type: Article Affiliation country: J.jaci.2021.09.008

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / COVID-19 / Immunologic Memory Type of study: Randomized controlled trials / Risk factors Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: J Allergy Clin Immunol Year: 2021 Document Type: Article Affiliation country: J.jaci.2021.09.008