The germinal centre B cell response to SARS-CoV-2.
Nat Rev Immunol
; 22(1): 7-18, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1555659
ABSTRACT
The germinal centre (GC) response is critical for the generation of affinity-matured plasma cells and memory B cells capable of mediating long-term protective immunity. Understanding whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or vaccination elicits a GC response has profound implications for the capacity of responding B cells to contribute to protection against infection. However, direct assessment of the GC response in humans remains a major challenge. Here we summarize emerging evidence for the importance of the GC response in the establishment of durable and broad immunity against SARS-CoV-2 and discuss new approaches to modulate the GC response to better protect against newly emerging SARS-CoV-2 variants. We also discuss new findings showing that the GC B cell response persists in the draining lymph nodes for at least 6 months in some individuals following vaccination with SARS-CoV-2 mRNA-based vaccines.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Germinal Center
/
COVID-19 Vaccines
/
SARS-CoV-2
/
COVID-19
/
Memory B Cells
Topics:
Vaccines
/
Variants
Limits:
Animals
/
Humans
Language:
English
Journal:
Nat Rev Immunol
Journal subject:
Allergy and Immunology
Year:
2022
Document Type:
Article
Affiliation country:
S41577-021-00657-1
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