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Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals.
Lim, Jackwee; Puan, Kia Joo; Wang, Liang Wei; Teng, Karen Wei Weng; Loh, Chiew Yee; Tan, Kim Peng; Carissimo, Guillaume; Chan, Yi-Hao; Poh, Chek Meng; Lee, Cheryl Yi-Pin; Fong, Siew-Wai; Yeo, Nicholas Kim-Wah; Chee, Rhonda Sin-Ling; Amrun, Siti Naqiah; Chang, Zi Wei; Tay, Matthew Zirui; Torres-Ruesta, Anthony; Leo Fernandez, Norman; How, Wilson; Andiappan, Anand Kumar; Lee, Wendy; Duan, Kaibo; Tan, Seow-Yen; Yan, Gabriel; Kalimuddin, Shirin; Lye, David Chien; Leo, Yee-Sin; Ong, Sean W X; Young, Barnaby E; Renia, Laurent; Ng, Lisa F P; Lee, Bernett; Rötzschke, Olaf.
  • Lim J; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Puan KJ; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Wang LW; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Teng KWW; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Loh CY; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Tan KP; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Carissimo G; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Chan YH; ASTAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore, Singapore.
  • Poh CM; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Lee CY; ASTAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore, Singapore.
  • Fong SW; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Yeo NK; ASTAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore, Singapore.
  • Chee RS; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Amrun SN; ASTAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore, Singapore.
  • Chang ZW; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Tay MZ; ASTAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore, Singapore.
  • Torres-Ruesta A; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
  • Leo Fernandez N; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • How W; ASTAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore, Singapore.
  • Andiappan AK; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Lee W; ASTAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore, Singapore.
  • Duan K; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Tan SY; ASTAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore, Singapore.
  • Yan G; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Kalimuddin S; ASTAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore, Singapore.
  • Lye DC; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Leo YS; ASTAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore, Singapore.
  • Ong SWX; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Young BE; ASTAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore, Singapore.
  • Renia L; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Ng LFP; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Lee B; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
  • Rötzschke O; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
Front Immunol ; 12: 710217, 2021.
Article in English | MEDLINE | ID: covidwho-1555700
ABSTRACT
Severe SARS-CoV-2 infection can trigger uncontrolled innate and adaptive immune responses, which are commonly associated with lymphopenia and increased neutrophil counts. However, whether the immune abnormalities observed in mild to severely infected patients persist into convalescence remains unclear. Herein, comparisons were drawn between the immune responses of COVID-19 infected and convalescent adults. Strikingly, survivors of severe COVID-19 had decreased proportions of NKT and Vδ2 T cells, and increased proportions of low-density neutrophils, IgA+/CD86+/CD123+ non-classical monocytes and hyperactivated HLADR+CD38+ CD8+ T cells, and elevated levels of pro-inflammatory cytokines such as hepatocyte growth factor and vascular endothelial growth factor A, long after virus clearance. Our study suggests potential immune correlates of "long COVID-19", and defines key cells and cytokines that delineate true and quasi-convalescent states.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Etiology study / Incidence study / Observational study / Risk factors Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.710217

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Etiology study / Incidence study / Observational study / Risk factors Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.710217