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[Epidemiology, clinical characteristics and treatment in 278 patients with coronavirus disease 2019 in Guangzhou].
Liu, C Q; Pan, Y J; Deng, X L; Luo, Y Y; Wei, G Y; Lao, W T; Zhang, G M; Luo, C W; Tan, X C; Guan, Y J; Lei, C L.
  • Liu CQ; Department of Emergency, Guangzhou Eighth People's Hospital, Guangzhou 510060, China.
  • Pan YJ; Department of Emergency, Guangzhou Eighth People's Hospital, Guangzhou 510060, China.
  • Deng XL; Department of Emergency, Guangzhou Eighth People's Hospital, Guangzhou 510060, China.
  • Luo YY; Department of Emergency, Guangzhou Eighth People's Hospital, Guangzhou 510060, China.
  • Wei GY; Department of Emergency, Guangzhou Eighth People's Hospital, Guangzhou 510060, China.
  • Lao WT; Department of Emergency, Guangzhou Eighth People's Hospital, Guangzhou 510060, China.
  • Zhang GM; Department of Emergency, Guangzhou Eighth People's Hospital, Guangzhou 510060, China.
  • Luo CW; Department of Emergency, Guangzhou Eighth People's Hospital, Guangzhou 510060, China.
  • Tan XC; Department of Emergency, Guangzhou Eighth People's Hospital, Guangzhou 510060, China.
  • Guan YJ; Department of Emergency, Guangzhou Eighth People's Hospital, Guangzhou 510060, China.
  • Lei CL; Department of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou 510060, China.
Zhonghua Nei Ke Za Zhi ; 59(8): 598-604, 2020 Aug 01.
Article in Chinese | MEDLINE | ID: covidwho-1555710
ABSTRACT

Objective:

To retrospective analyze the epidemiology, clinical characteristics, treatment and prognosis in patients with coronavirus disease 2019 (COVID-19).

Methods:

A total of 278 patients with COVID-19 admitted to Guangzhou Eighth People's Hospital from January 20 to February 10, 2020 were selected. The general demographic data, epidemiological data, clinical symptoms, laboratory examinations, lung CT imaging, treatment and prognosis were analyzed.

Results:

There were 130 male patients (46.8%) and 148 females (53.2%) with age (48.1±17.0) years and 88.8% patients between 20-69 years. Two hundred and thirty-six (84.9%) patients had comorbidities. Two hundred and eleven cases (75.9%) were common type. The in-hospital mortality was 0.4% (1/278). The majority (201, 72.3%) were imported cases mainly from Wuhan (89, 44.3%). The most common clinical manifestations were fever (70.9%) and dry cough (61.5%). In some patients, hemoglobin (10.4%), platelets (12.6%) and albumin (55.4%) were lower than the normal range. Other biochemical tests according to liver and function were normal, while lactic dehydrogenase (LDH) was elevated in 61 patients (21.9%), creatine kinase increased in 26 patients (9.4%). Prolonged activated partial thromboplastin time (APTT) was seen in 52 patients (18.7%), D-dimer higher than normal in 140 patients (50.4%), while 117 patients (42.1%) had elevated high-sensitivity C-reactive protein. Typical CT manifestations included single or multiple ground glass shadows especially in lung periphery in early disease which infiltrated and enlarged during progressive stage. Diffuse consolidation with multiple patchy density in severe/critical cases and even "white lung" presented in a few patients. Two hundred and forty-two patients (87.1%) received one or more antiviral agents, 242 (87.1%) combined with antibacterials, 191 (68.7%) with oxygen therapy. There were 198 patients (71.2%) treated with traditional Chinese medicine.

Conclusions:

COVID-19 could attack patients in all ages with majority of common type and low mortality rate. Clinical manifestations involve multiple organs or systems. Progression of the disease results in critical status which should be paid much attention.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Screening study Topics: Traditional medicine Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: Chinese Journal: Zhonghua Nei Ke Za Zhi Year: 2020 Document Type: Article Affiliation country: Cma.j.cn112138-20200317-00250

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Screening study Topics: Traditional medicine Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: Chinese Journal: Zhonghua Nei Ke Za Zhi Year: 2020 Document Type: Article Affiliation country: Cma.j.cn112138-20200317-00250