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The Predictive Value of Myoglobin for COVID-19-Related Adverse Outcomes: A Systematic Review and Meta-Analysis.
Ma, Chaoqun; Tu, Dingyuan; Gu, Jiawei; Xu, Qiang; Hou, Pan; Wu, Hong; Guo, Zhifu; Bai, Yuan; Zhao, Xianxian; Li, Pan.
  • Ma C; Department of Cardiology, Changhai Hospital, Naval Medical University, Shanghai, China.
  • Tu D; Department of Cardiology, Changhai Hospital, Naval Medical University, Shanghai, China.
  • Gu J; Department of General Surgery, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
  • Xu Q; Department of Cardiology, Changhai Hospital, Naval Medical University, Shanghai, China.
  • Hou P; Department of Cardiology, Changhai Hospital, Naval Medical University, Shanghai, China.
  • Wu H; Department of Cardiology, Changhai Hospital, Naval Medical University, Shanghai, China.
  • Guo Z; Department of Cardiology, Changhai Hospital, Naval Medical University, Shanghai, China.
  • Bai Y; Department of Cardiology, Changhai Hospital, Naval Medical University, Shanghai, China.
  • Zhao X; Department of Cardiology, Changhai Hospital, Naval Medical University, Shanghai, China.
  • Li P; Department of Cardiology, Changhai Hospital, Naval Medical University, Shanghai, China.
Front Cardiovasc Med ; 8: 757799, 2021.
Article in English | MEDLINE | ID: covidwho-1555742
ABSTRACT

Objective:

Cardiac injury is detected in numerous patients with coronavirus disease 2019 (COVID-19) and has been demonstrated to be closely related to poor outcomes. However, an optimal cardiac biomarker for predicting COVID-19 prognosis has not been identified.

Methods:

The PubMed, Web of Science, and Embase databases were searched for published articles between December 1, 2019 and September 8, 2021. Eligible studies that examined the anomalies of different cardiac biomarkers in patients with COVID-19 were included. The prevalence and odds ratios (ORs) were extracted. Summary estimates and the corresponding 95% confidence intervals (95% CIs) were obtained through meta-analyses.

Results:

A total of 63 studies, with 64,319 patients with COVID-19, were enrolled in this meta-analysis. The prevalence of elevated cardiac troponin I (cTnI) and myoglobin (Mb) in the general population with COVID-19 was 22.9 (19-27%) and 13.5% (10.6-16.4%), respectively. However, the presence of elevated Mb was more common than elevated cTnI in patients with severe COVID-19 [37.7 (23.3-52.1%) vs.30.7% (24.7-37.1%)]. Moreover, compared with cTnI, the elevation of Mb also demonstrated tendency of higher correlation with case-severity rate (Mb, r = 13.9 vs. cTnI, r = 3.93) and case-fatality rate (Mb, r = 15.42 vs. cTnI, r = 3.04). Notably, elevated Mb level was also associated with higher odds of severe illness [Mb, OR = 13.75 (10.2-18.54) vs. cTnI, OR = 7.06 (3.94-12.65)] and mortality [Mb, OR = 13.49 (9.3-19.58) vs. cTnI, OR = 7.75 (4.4-13.66)] than cTnI.

Conclusions:

Patients with COVID-19 and elevated Mb levels are at significantly higher risk of severe disease and mortality. Elevation of Mb may serve as a marker for predicting COVID-19-related adverse outcomes. Prospero Registration Number https//www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020175133, CRD42020175133.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Language: English Journal: Front Cardiovasc Med Year: 2021 Document Type: Article Affiliation country: Fcvm.2021.757799

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Language: English Journal: Front Cardiovasc Med Year: 2021 Document Type: Article Affiliation country: Fcvm.2021.757799