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Raman Molecular Fingerprints of SARS-CoV-2 British Variant and the Concept of Raman Barcode.
Pezzotti, Giuseppe; Boschetto, Francesco; Ohgitani, Eriko; Fujita, Yuki; Shin-Ya, Masaharu; Adachi, Tetsuya; Yamamoto, Toshiro; Kanamura, Narisato; Marin, Elia; Zhu, Wenliang; Nishimura, Ichiro; Mazda, Osam.
  • Pezzotti G; Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, Kyoto, 606-8585, Japan.
  • Boschetto F; Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, 465 Kajii-cho, Kyoto, 602-8566, Japan.
  • Ohgitani E; Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
  • Fujita Y; The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0854, Japan.
  • Shin-Ya M; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
  • Adachi T; Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, 602-8566, Japan.
  • Yamamoto T; Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, Kyoto, 606-8585, Japan.
  • Kanamura N; Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, 465 Kajii-cho, Kyoto, 602-8566, Japan.
  • Marin E; Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, 465 Kajii-cho, Kyoto, 602-8566, Japan.
  • Zhu W; Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, Kyoto, 606-8585, Japan.
  • Nishimura I; Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, 465 Kajii-cho, Kyoto, 602-8566, Japan.
  • Mazda O; Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, 602-8566, Japan.
Adv Sci (Weinh) ; 9(3): e2103287, 2022 01.
Article in English | MEDLINE | ID: covidwho-1557802
ABSTRACT
The multiple mutations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus have created variants with structural differences in both their spike and nucleocapsid proteins. While the functional relevance of these mutations is under continuous scrutiny, current findings have documented their detrimental impact in terms of affinity with host receptors, antibody resistance, and diagnostic sensitivity. Raman spectra collected on two British variant sub-types found in Japan (QK002 and QHN001) are compared with that of the original Japanese isolate (JPN/TY/WK-521), and found bold vibrational differences. These included i) fractions of sulfur-containing amino acid rotamers, ii) hydrophobic interactions of tyrosine phenol ring, iii) apparent fractions of RNA purines and pyrimidines, and iv) protein secondary structures. Building upon molecular scale results and their statistical validations, the authors propose to represent virus variants with a barcode specially tailored on Raman spectrum. Raman spectroscopy enables fast identification of virus variants, while the Raman barcode facilitates electronic recordkeeping and translates molecular characteristics into information rapidly accessible by users.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spectrum Analysis, Raman / Nucleocapsid Proteins / Spike Glycoprotein, Coronavirus / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Variants Limits: Humans Country/Region as subject: Europa Language: English Journal: Adv Sci (Weinh) Year: 2022 Document Type: Article Affiliation country: Advs.202103287

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spectrum Analysis, Raman / Nucleocapsid Proteins / Spike Glycoprotein, Coronavirus / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Variants Limits: Humans Country/Region as subject: Europa Language: English Journal: Adv Sci (Weinh) Year: 2022 Document Type: Article Affiliation country: Advs.202103287