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Chemical Synthesis of the Anti-COVID-19 Drug Remdesivir.
Wang, Mo; Zhang, Lu; Huo, Xiaohong; Zhang, Zhenfeng; Zhang, Wanbin.
  • Wang M; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Zhang L; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
  • Huo X; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
  • Zhang Z; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Zhang W; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Curr Protoc ; 1(12): e303, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1557813
ABSTRACT
Remdesivir has become an important compound for the treatment of COVID-19. Here, we describe the catalytic asymmetric synthesis of this anti-COVID-19 drug. First, the P-racemic phosphoryl chloride is synthesized in a facile procedure. Then, it is possible to obtain the protected remdesivir via the organocatalytic asymmetric phosphorylation of protected nucleoside GS441524 with P-racemic phosphoryl chloride catalyzed by chiral bicyclic imidazole. Finally, remdesivir is easily prepared by deprotection. © 2021 Wiley Periodicals LLC. Basic Protocol 1 Synthesis of 2-ethylbutyl (chloro(phenoxy)phosphoryl)-L-alaninate rac-4 Basic Protocol 2 Synthesis of chiral bicyclic imidazole Ad-DPI Basic Protocol 3 Synthesis of remdesivir.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pharmaceutical Preparations / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Curr Protoc Year: 2021 Document Type: Article Affiliation country: Cpz1.303

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pharmaceutical Preparations / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Curr Protoc Year: 2021 Document Type: Article Affiliation country: Cpz1.303