Chemical Synthesis of the Anti-COVID-19 Drug Remdesivir.
Curr Protoc
; 1(12): e303, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1557813
ABSTRACT
Remdesivir has become an important compound for the treatment of COVID-19. Here, we describe the catalytic asymmetric synthesis of this anti-COVID-19 drug. First, the P-racemic phosphoryl chloride is synthesized in a facile procedure. Then, it is possible to obtain the protected remdesivir via the organocatalytic asymmetric phosphorylation of protected nucleoside GS441524 with P-racemic phosphoryl chloride catalyzed by chiral bicyclic imidazole. Finally, remdesivir is easily prepared by deprotection. © 2021 Wiley Periodicals LLC. Basic Protocol 1 Synthesis of 2-ethylbutyl (chloro(phenoxy)phosphoryl)-L-alaninate rac-4 Basic Protocol 2 Synthesis of chiral bicyclic imidazole Ad-DPI Basic Protocol 3 Synthesis of remdesivir.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pharmaceutical Preparations
/
COVID-19 Drug Treatment
Limits:
Humans
Language:
English
Journal:
Curr Protoc
Year:
2021
Document Type:
Article
Affiliation country:
Cpz1.303
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