In silico screening of the active compounds of Syzygium cumini (L.) Skeels. as anti-coronavirus

ABSTRACT

Coronavirus disease-19 (Covid-19) has been pandemic since 2019 and the world is still trying to cope with it. Even though there is a new hope with the invention of the vaccine, the virus has rapid mutation rate. Therefore alternative solutions are necessary and one of them is using the herbs with their active compounds. Syzygium cumini (L.) Skeels. is a species of Myrtaceae containing various phytochemical compounds with medicinal activity, such as anti-oxidants, anti-inflammatory, anti-cancer, anti-tumour, anti-diabetes and anti-microbial. Previous studies showed that several compound contained in S. cumini had the potential of having anti-coronavirus activities. This study aimed to determine the phytochemical compounds of S. cumini and to screen their potential as an anti-coronavirus. The method used in this research were literature study and molecular docking. The results showed that S. cumini contained the active compounds of anti-coronavirus, namely betulinic acid, kaempferol, malvidin, myricetin and quercetin. Those compounds are contained in the bark of S. cumini.